激活素受体样激酶1 在血管发育和脑血管疾病中的作用

JM Hong, YD Hu, XQ Chai, CL Tang - 中国神经再生研究(英文版), 2020 - sjzsyj.com.cn
Activin receptor-like kinase 1 (ALK1) is a transmembrane serine/threonine receptor kinase of
the transforming growth factor beta (TGFβ) receptor superfamily. ALK1 is specifically …

[HTML][HTML] Role of activin receptor-like kinase 1 in vascular development and cerebrovascular diseases

JM Hong, YD Hu, XQ Chai, CL Tang - Neural Regeneration …, 2020 - journals.lww.com
Activin receptor-like kinase 1 (ALK1) is a transmembrane serine/threonine receptor kinase of
the transforming growth factor beta (TGFβ) receptor superfamily. ALK1 is specifically …

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

SP Oh, T Seki, KA Goss, T Imamura… - Proceedings of the …, 2000 - National Acad Sciences
The activin receptor-like kinase 1 (ALK1) is a type I receptor for transforming growth factor-β
(TGF-β) family proteins. Expression of ALK1 in blood vessels and mutations of the ALK1 …

Isolation of a regulatory region of activin receptor-like kinase 1 gene sufficient for arterial endothelium-specific expression

T Seki, KH Hong, J Yun, SJ Kim, SP Oh - Circulation research, 2004 - Am Heart Assoc
Activin receptor-like kinase 1 (Acvrl1; Alk1) is a type I receptor for transforming growth factor-
β (TGF-β). ALK1 plays a pivotal role in vascular development and is involved in the …

[HTML][HTML] Casein kinase 2β as a novel enhancer of activin-like receptor-1 signaling

NY Lee, JC Haney, J Sogani, GC Blobe - The FASEB Journal, 2009 - ncbi.nlm.nih.gov
ALK-1 is a transforming growth factor β (TGF-β) superfamily receptor that is predominantly
expressed in endothelial cells and is essential for angiogenesis, as demonstrated by the …

Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling

T Seki, J Yun, SP Oh - Circulation research, 2003 - Am Heart Assoc
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder
characterized by epistaxis, mucocutaneous telangiectases, and arteriovenous …

[HTML][HTML] Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1

EM Garrido-Martin, FJ Blanco, A Fernandez-L… - BMC molecular …, 2010 - Springer
Background Activin receptor-like kinase 1 (ALK1) is a Transforming Growth Factor-β (TGF-β)
receptor type I, mainly expressed in endothelial cells that plays a pivotal role in vascular …

The role of ALK1 and ALK5 in HUVECs and human ES cell derived endothelial cells

JF Rúnarsson - 2013 - skemman.is
Since human embryonic stem cells (hES cells) were discovered they have been studied
intensively, revealing hES cells as a powerful research tool for understanding early …

ALK1 signaling in development and disease: new paradigms

BL Roman, AP Hinck - Cellular and molecular life sciences, 2017 - Springer
Activin A receptor like type 1 (ALK1) is a transmembrane serine/threonine receptor kinase in
the transforming growth factor-beta receptor family that is expressed on endothelial cells …

Bone Marrow-Derived Alk1 Mutant Endothelial Cells and Clonally Expanded Somatic Alk1 Mutant Endothelial Cells Contribute to the Development of Brain …

SS Shaligram, R Zhang, W Zhu, L Ma, M Luo… - Translational stroke …, 2021 - Springer
We have previously demonstrated that deletion of activin receptor-like kinase 1 (Alk1) or
endoglin in a fraction of endothelial cells (ECs) induces brain arteriovenous malformations …