Diffuse human gliomas constitute a group of most treatment-refractory tumors even if
maximum treatment strategies including neurosurgical resection followed by combined radio …

Tumors of glial origin consist of a core mass and a penumbra of invasive, single cells,
decreasing in numbers towards the periphery and still detectable several centimeters away …

Local invasion of the brain by neoplastic glial cells is a major obstacle to effective treatment
of intrinsic brain tumors. Invasion is directly related to histologic malignancy, but occurs to …

Gliomas are the most common intracranial tumors. In the US, approximately 15,000 patients
die with glioblastoma per year (CBTRUS 2002). Despite modern diagnostics and treatments …

Glioblastoma multiforme (GBM) is one of the most common and most aggressive types of
primary brain tumors in humans. Even with aggressive surgical resections using state of the …

Glioblastoma multiforme is the most common and lethal primary malignant brain tumor.
Although considerable progress has been made in technical proficiencies of surgical and …

High-grade gliomas are especially difficult tumors to treat due to their invasive behavior. This
has led to extensive research focusing on arresting glioma cell migration. Cell migration …

Although significant technical advances in surgical and radiation treatment for brain tumors
have emerged in recent years, their impact on clinical outcome for patients has been …

Glioblastomas are the most common and lethal form of malignant primary brain tumors.
Although some progress has been made, the impact of recent advances in multimodality …

A hallmark of gliomas is the ability of individual tumor cells to infiltrate the neural tissue and
extend beyond the visible borders of the tumor. Current treatments fail to remove these …