直接口服抗凝剂: 一种针对阿尔茨海默病的新疗法?

K Grossmann - 中国神经再生研究(英文版), 2021 - sjzsyj.com.cn
More than 40 million people worldwide are thought to be affected by Alzheimers disease
(AD). Of these, estimated less than 10% develop symptoms usually well before the age of …

Direct oral anticoagulants: a new therapy against Alzheimer's disease?

K Grossmann - Neural Regeneration Research, 2021 - journals.lww.com
More than 40 million people worldwide are thought to be affected by Alzheimers disease
(AD). Of these, estimated less than 10% develop symptoms usually well before the age of …

Anticoagulants for treatment of Alzheimer's disease

K Grossmann - Journal of Alzheimer's disease, 2020 - content.iospress.com
Alzheimer's disease (AD) is a multifactorial syndrome with a plethora of progressive,
degenerative changes in the brain parenchyma, but also in the cerebrovascular and …

Oral anticoagulants: A plausible new treatment for Alzheimer's disease?

R Toribio‐Fernandez, C Ceron… - British Journal of …, 2024 - Wiley Online Library
Alzheimer's disease (AD) and cardiovascular disease (CVD) are strongly associated. Both
are multifactorial disorders with long asymptomatic phases and similar risk factors. Indeed …

Direct oral anticoagulants (DOACs) for therapeutic targeting of thrombin, a key mediator of cerebrovascular and neuronal dysfunction in Alzheimer's disease

K Grossmann - Biomedicines, 2022 - mdpi.com
Although preclinical research and observer studies on patients with atrial fibrillation
concluded that direct oral anticoagulants (DOACs) can protect against dementia like …

Effects of dabigatran in mouse models of aging and cerebral amyloid angiopathy

N Michael, MM Grigoryan, K Kilday, RK Sumbria… - Frontiers in …, 2019 - frontiersin.org
Oral anticoagulants are a critical component of stroke prevention, but carry a risk of brain
hemorrhage. These hemorrhagic complications tend to occur in elderly individuals …

[HTML][HTML] Dabigatran reduces thrombin-induced neuroinflammation and AD markers in vitro: Therapeutic relevance for Alzheimer's disease

SW Bihaqi, HV Rao, A Sen, P Grammas - Cerebral Circulation-Cognition …, 2021 - Elsevier
Background Vascular risk factors such as atherosclerosis, diabetes, and elevated
homocysteine levels are strongly correlated with onset of Alzheimer's disease (AD) …

Prevalence, safety, and effectiveness of oral anticoagulant use in people with and without dementia or cognitive impairment: a systematic review and meta-analysis

L Fanning, TE Ryan-Atwood, JS Bell… - Journal of …, 2018 - content.iospress.com
Background: Differences in management and outcomes of oral anticoagulant (OAC) use
may exist for people with and without dementia or cognitive impairment (CI). Objective: To …

Oral anticoagulants and risk of dementia: a systematic review and meta-analysis of observational studies and randomized controlled trials

P Mongkhon, AY Naser, L Fanning, G Tse… - Neuroscience & …, 2019 - Elsevier
Atrial fibrillation (AF) is a documented risk factor for dementia. However, it is unclear whether
oral anticoagulant (OAC) treatment can reduce the development of dementia or cognitive …

[PDF][PDF] Efficacy and Safety of Direct Oral Anticoagulant for Treatment of Atrial Fibrillation in Cerebral Amyloid Angiopathy

K Narita, E Amiya, I Komuro - Cureus, 2020 - cureus.com
A 75-year-old man with a history of atrial fibrillation (AF) and anticoagulant therapy
presented with a headache. Cerebral amyloid angiopathy (CAA) was diagnosed after MRI of …