Abstract Treatment-resistant schizophrenia (TRS) is defined as a non-response to at least
two trials of antipsychotic medication with an adequate dose and duration. We aimed to …

DNA methylation, which is the transference of a methyl group to the 5′-carbon position of
the cytosine in a CpG dinucleotide, is one of the major mechanisms of epigenetic …

Objective Schizophrenia (SCZ) is a debilitating disease with a complex genetic cause in
which age at onset may reflect genetic vulnerability. Though there has been some …

Introduction: Schizophrenia is a chronic neuropsychiatric disease with a lifetime incidence
rate of 1.41% in India. Antipsychotics are a major treatment option for alleviating psychotic …

Background Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to
result from disturbances in early brain development. There is mounting evidence to support …

Schizophrenia (SZ) is severe neuropsychiatric disorder with significant costs to the
individual and society. Accumulating evidence points to the role of DNA methylation (DNAm) …

Psychiatric disorder diagnoses are heavily reliant on the Diagnostic and Statistical Manual
of Mental Disorders' listing of observable symptoms and clinical traits, the skill level of the …

Given the difficulty of procuring human brain tissue, a key question in molecular psychiatry
concerns the extent to which epigenetic signatures measured in more accessible tissues …

Sex differences in the epidemiology and clinical characteristics of schizophrenia are well-
known; however, the molecular mechanisms underlying these differences remain unclear …

Schizophrenia and bipolar disorder share biological features and environmental risk factors
that may be associated with altered DNA methylation. In this study we sought to: 1) construct …