Provincial Hospital from Febr uary 2007 to March 2008 were selected. Of the 64 patients, 46
were men and 18 were women, aged of 33 107 years with a median of 60 years. No patients …

Background: Recently, aberrant methylation of the CHFR gene associated with gene
silencing has been reported in several cancers. The methylation status of the CHFR gene …

AIM: To investigate the aberrant methylation of CHFR promoter in human gastric cancer
(GC) and its impact on the expression of CHFR mRNA and protein, as well as its correlation …

While chromosomal instability is a common feature of human solid tumours, no
abnormalities in genes involved in the mitotic checkpoint have been identified. However …

Background: Chromosomally unstable tumors account for 50% of gastric cancer. CHFR
plays a role in controlling chromosomal instability and its inactivation will eventually lead to …

The mitotic checkpoint gene (CHFR)(Checkpoint with Forkhead-associated and Ring finger
domains is a G2 phase/mitosis checkpoint and tumor-suppressor gene. Recent studies have …

Background: Aberrant methylation of the CHFR gene associated with gene silencing has
been reported in several primary tumors. In order to define the role of CHFR in the …

Recent studies have shown that promoter hypermethylation of tumor suppressor genes is an
important factor in carcinogenesis of several human organs. The purpose of this study was …

Chromosomal instability (CIN) is a cytogenetic hallmark of human cancers. Increasing
evidence suggests that impairment of mitotic checkpoint is causally associated with CIN …

BACKGROUND: The checkpoint with forkhead‐associated domain and RING‐finger domain
(CHFR) is a mitotic checkpoint protein with tumor‐suppressor functions. In this study, the …