质谱成像(MSI) 作为一种无标记的分子成像技术, 弥补了传统液质联用等分析技术空间分辨能力
的不足, 已被广泛应用于小分子代谢物, 脂质, 多肽及蛋白质的组织分布研究. 随着MSI …

Mass spectrometry imaging (MSI), a label-free molecular imaging technique, has been
applied widely in the spatial localization of small molecule metabolites, lipids, peptides, and …

质谱成像是一种在组织, 细胞或亚细胞水平研究分子或离子种类及分布的新型分析技术,
无需复杂前处理即可实现样本表面多种物质的原位定性, 定量分析, 绘制出它们的空间分布图 …

Highlights•An overview of recent advances in MSI for drug localization is presented.•MSI
provides label-free imaging of drugs and metabolites at high lateral resolution.•Spatial …

In the past decade, mass spectrometry imaging (MSI) has received an increasing amount of
attention due to its ability in displaying the spatial distribution of a wide range of molecules …

Understanding the biodistribution, metabolism and accumulation of drugs in the body is a
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …

Over the past three decades, mass spectrometry imaging (MSI) has emerged as a valuable
tool for the spatial localization of drugs and metabolites directly from tissue surfaces without …

Since its introduction mass spectrometry imaging (MSI) has proven to be a powerful tool for
the localization of molecules in biological tissues. In drug discovery and development …

Although liquid chromatography-tandem mass spectrometry is the gold standard analytical
platform for the quantification of drugs, metabolites, and biomarkers in biological samples, it …

Mass spectrometric imaging (MSI) has rapidly increased its presence in the pharmaceutical
sciences. While quantitative whole-body autoradiography and microautoradiography are the …