三维基因组染色质架构蛋白CTCF (CCCTC-binding factor) 能够介导增强子与基因启动子的远
距离染色质相互作用, 也可以结合调控区域的绝缘子发挥增强子绝缘功能, 对发育中的基因表达 …

The genome architectural protein CTCF (CCCTC-binding factor) not only mediates long-
distance chromatin interactions between distal enhancers and target promoters, but also …

CTCF (CCCTC-binding factor) 是一种重要的染色质架构蛋白, 其与绝缘子的方向性结合在哺乳
动物基因组三维空间结构形成和维持中起着至关重要的作用. 正向-反向相对方向的CTCF …

Mammalian Hox gene clusters contain a range of CTCF binding sites. In addition to their
importance in organizing a TAD border, which isolates the most posterior genes from the …

Modulation of chromatin structure has been proposed as a molecular mechanism underlying
the spatiotemporal collinear expression of Hox genes during development. CCCTC‐binding …

Hox 基因是生物体内一类重要的发育调控基因家族. Hox 基因高度保守, 通常成簇存在,
编码一类转录因子, 在个体胚胎发育中起着重要的调控作用. 近期研究表明, 基因复制 …

CCCTC-binding factor (CTCF)-mediated stable topologically associating domains (TADs)
play a critical role in constraining interactions of DNA elements that are located in …

HOX cluster genes are activated sequentially in their positional order along the chromosome
during vertebrate development. This phenomenon, known as temporal colinearity, depends …

In this issue of Genes & Development, Amândio and colleagues (pp. 1490–1509) dissect the
function of a cluster of several CTCF binding sites in the HoxD cluster by iterative deletions …

Precise Hox gene expression is crucial for embryonic patterning. Intra-Hox transcription
factor binding and distal enhancer elements have emerged as the major regulatory modules …