近年来白介素(IL)-12/IL-23γ-干扰素(IFN-γ) 轴对于分枝杆菌的免疫作用日益受到关注,
对于该轴系的研究也在不断地深入. 累及IFNγ-受体1 (IFNγ-R1), IFNγ-受体2 (IFNγ-R2), IL-12 …

Abstract Background The IL-12/23/ISG15-IFN-γ pathway is the main immunological pathway
for controlling intra-macrophagic microorganisms such as Mycobacteria, Salmonella, and …

目的探讨1 例疑似孟德尔遗传易感分枝杆菌病(Mendelian susceptibility to mycobacterial
disease, MSMD) 患儿的临床特征, 检测IL-12/23-IFN-γ 通路的完整性, 并进行IFN-γ 受体1 …

Mendelian Susceptibility to Mycobacterial Diseases (MSMD) is a primary immunodeficiency
disease (PID) characterized by variable susceptibility to weakly virulent mycobacteria …

Purpose The aim of this study is to investigate clinical characteristics and genetic
backgrounds of Mendelian susceptibility to mycobacterial diseases (MSMD) in Japan …

Abstract The interleukin (IL)-12/interferon (IFN) γ axis plays an important role in the control of
mycobacterial diseases as demonstrated by the increased susceptibility to mycobacterial …

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare congenital condition
characterized by a selective predisposition to infections caused by weakly virulent …

Clinical disease caused by weakly pathogenic mycobacterial species, Mycobacterium bovis
Bacille Calmette-Guérin (BCG) and non-tuberculous environmental mycobacteria (EM) …

BACKGROUND/OBJECTIVE: The IL-12–IFN-γ axis is critical for immune defense against
mycobacterial infections. Inherited mutations that affect normal activation of this self …

Infection with Mycobacterium tuberculosis results in disease in 5–10% of exposed
individuals, whereas the remainder controls infection effectively. Similar inter-individual …