EN1 调节UTROPHIN 表达机制
王谦， 曹东华， 林长坤， 王正东， 崔婉婷， 金春莲 - 遗传, 2011 - chinagene.cn
为了探讨人类UTROPHIN 蛋白表达上调的可能因素, 文章利用P-match 软件预测人类
UTROPHIN 基因启动子区域可能的调控元件, 应用CHIP 和EMSA 实验加以验证, 并利用RNA …
UTROPHIN 基因启动子区域可能的调控元件, 应用CHIP 和EMSA 实验加以验证, 并利用RNA …
A method of utrophin up-regulation through RNAi-mediated knockdown of the transcription factor EN1
Q Wang, DH Cao, CL Jin, CK Lin… - Journal of …, 2011 - journals.sagepub.com
The aim of this study was to induce up-regulation of the dystrophin-related gene UTRN that
encodes the protein utrophin, to determine whether this could compensate for the lack of …
encodes the protein utrophin, to determine whether this could compensate for the lack of …
[HTML][HTML] Utrophin transcription is activated by an intronic enhancer
F Galvagni, S Oliviero - Journal of Biological Chemistry, 2000 - ASBMB
The utrophin gene codes for a large cytoskeletal protein closely related to dystrophin. Its
transcription is driven by a TATA-less promoter. Here we analyzed 40 kilobases of the 5 …
transcription is driven by a TATA-less promoter. Here we analyzed 40 kilobases of the 5 …
A 1.3 kb promoter fragment confers spatial and temporal expression of utrophin A mRNA in mouse skeletal muscle fibers
MA Stocksley, JV Chakkalakal, A Bradford… - Neuromuscular …, 2005 - Elsevier
Upregulation of utrophin in muscle is currently being examined as a potential therapy for
Duchenne muscular dystrophy patients. In this context, we generated transgenic mice …
Duchenne muscular dystrophy patients. In this context, we generated transgenic mice …
A cell-based high-throughput screening assay for posttranscriptional utrophin upregulation
C Moorwood, N Soni, G Patel… - Journal of …, 2013 - journals.sagepub.com
Duchenne muscular dystrophy (DMD) is a devastating muscle-wasting disease caused by
mutations in the dystrophin gene. Utrophin is a homologue of dystrophin that can …
mutations in the dystrophin gene. Utrophin is a homologue of dystrophin that can …
Downstream utrophin enhancer is required for expression of utrophin in skeletal muscle
J Tanihata, N Suzuki, Y Miyagoe‐Suzuki… - The Journal of Gene …, 2008 - Wiley Online Library
Background Duchenne muscular dystrophy is caused by the absence of the muscle
cytoskeletal protein dystrophin. Utrophin is an autosomal homologue of dystrophin, and …
cytoskeletal protein dystrophin. Utrophin is an autosomal homologue of dystrophin, and …
[图书][B] Transcription of the utrophin gene: identification and characterisation of novel transcripts
JB Wilson - 2000 - search.proquest.com
Utrophin is a large protein, which accummulates at the neuromuscular and myotendinous
junctions in the adult skeletal muscle, and is widely expressed in several non-muscle …
junctions in the adult skeletal muscle, and is widely expressed in several non-muscle …
[引用][C] ''A study of short utrophin isoforms in mice defi-cient for full-length utrophin,''by C. Jimenez-Mallebrera, K. Davis, W. Putt, YH Edwards. Volume 14/number 1 …
M Pearce, DJ Blake, JM Tinsley, BC Byth - search.proquest.com
Pearce M, Blake DJ, Tinsley JM, Byth BC, Campbell L, Monaco AP, and Davies KE.(The
utrophin and dystrophin genes share similarities in genomic structure. Hum Mol Genet 2 …
utrophin and dystrophin genes share similarities in genomic structure. Hum Mol Genet 2 …
[HTML][HTML] Cis-acting sequence elements and upstream open reading frame in Mouse Utrophin-A 5'-UTR Repress cap-Dependent Translation
T Ghosh, U Basu - PLoS One, 2015 - journals.plos.org
Utrophin, the autosomal homologue of dystrophin can functionally compensate for
dystrophin deficiency. Utrophin upregulation could therefore be a therapeutic strategy in …
dystrophin deficiency. Utrophin upregulation could therefore be a therapeutic strategy in …