脓毒症诊治中Ang/Tie 信号通路的研究进展

杨航, 戴菁, 王学锋 - 诊断学理论与实践, 2024 - qk.sjtu.edu.cn
脓毒症以及伴随的多器官功能障碍是一组常见的临床综合征, 其患病率随着人口老龄化逐年上升
. 全球每年发生2 000 万例脓毒症, 死亡率为26%. 早期准确诊断脓毒症, 有利于及时采取针对性 …

Advances in the study on Ang/Tie signaling pathway in diagnosis and treatment of sepsis

Y Hang, DAI Jing, W Xuefeng - Journal of Diagnostics Concepts & …, 2024 - qk.sjtu.edu.cn
Sepsis and concomitant multiorgan dysfunction are a group of common clinical syndromes,
and their prevalence are increasing year by year due to the increase of the aging …

Role of Angiopoietin/Tie2 System in Sepsis: A Potential Therapeutic Target

Y Chi, S Yu, J Yin, D Liu, M Zhuo… - Clinical and Applied …, 2024 - journals.sagepub.com
Sepsis is a disorder of host response caused by severe infection that can lead to life-
threatening organ dysfunction. There is no specific treatment for sepsis. Although there are …

Endothelial activation: the Ang/Tie axis in sepsis

A Leligdowicz, M Richard-Greenblatt, J Wright… - Frontiers in …, 2018 - frontiersin.org
Sepsis, a dysregulated host response to infection that causes life-threatening organ
dysfunction, is a highly heterogeneous syndrome with no specific treatment. Although sepsis …

Special focus: endothelial activation/dysfunction

WC Liles - Virulence, 2013 - Taylor & Francis
Correspondence to: W Conrad Liles; Email: wcliles@ uw. edu Submitted: 07/27/2013;
Accepted: 07/28/2013 http://dx. doi. org/10.4161/viru. 26018 dysfunction in order to guide …

Year in review in Intensive Care Medicine 2013: III. Sepsis, infections, respiratory diseases, pediatrics

JF Timsit, G Citerio, J Bakker, M Bassetti, D Benoit… - Intensive care …, 2014 - Springer
Dobutamine has been widely advocated to improve (inadequate) cardiac output in septic
shock. However, on the basis of the double-blind, crossover, randomized study from …

The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury

M van der Heijden… - Expert opinion on …, 2009 - Taylor & Francis
Background: Sepsis and acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)
are life-threatening syndromes characterised by inflammation and increased vascular …

Dysfunctional endothelium drives a Pre-DIC state in endotoxemia

KEP De Ceunynck, SJ Higgins, SA Chaudhry, S Parikh… - Blood, 2016 - Elsevier
Uncontrolled pro-coagulant responses in sepsis can lead to disseminated intravascular
coagulation (DIC), a complication associated with markedly increased mortality …

Dysregulation of the angiopoietin–Tie-2 axis in sepsis and ARDS

SM Parikh - Virulence, 2013 - Taylor & Francis
Dynamic changes in microvascular endothelial structure and function are pivotal in the acute
inflammatory response, the body's rapid, coordinated effort to localize, sequester, and …

[PDF][PDF] 血循环中Tie2 mRNA 含量对脓毒症患者全身病情变化评价作用的研究

杨京, 黄健, 杨文琼, 周建, 蒋东坡, 张耀宗… - 中国危重病急救 …, 2010 - cccm-em120.com
目的探讨血循环中Tie2 mRNA 含量是否与脓毒症全身病情变化存在相关关系.
方法选取重症监护病房(ICU) 创伤患者, 按是否为脓毒症分为脓毒症组(13 例) 和非脓毒症组(19 …