哺乳动物肺对于血液与外部环境之间的气体交换至关重要. 而肺相关的疾病是现代人死亡的主要
原因之一. 肺的发育, 再生和相关疾病的研究对临床治疗具有重要的指导作用. 研究发现, Hippo …

function between the circulation and the atmospheric environment. Lung diseases, including
lung cancer, are among the leading causes of death in the modern society. Research on …

ppo 信号通路在维持细胞增殖, 凋亡平衡和控制细胞分化等方面发挥着重要的作用,
主要的生物学意义在于控制多细胞生物发育过程中各个器官的尺寸大小. 最近多项研究发现该 …

The hippo signaling pathway is a highly conserved evolutionary signaling pathway that
plays an important role in regulating cell proliferation, organ size, tissue development, and …

Hippo signaling pathway and its effector YAP have been recognized as an essential growth
regulator during embryonic development. Hippo has been studied in different contexts; …

Background: Bronchopulmonary dysplasia (BPD) is one of the most common causes of
death and morbidity in extremely low birth weight (ELBW) infants. It is characterized by …

Background: Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes-associated
protein (YAP) are key downstream effectors of the Hippo pathway. TAZ is considered as a …

The Hippo pathway is comprised of a kinase cascade that involves mammalian Ste20-like
serine/threonine kinases (MST1/2) and large tumor suppressor kinases (LATS1/2) and leads …

The Hippo pathway controls progenitor cell expansion, differentiation and organ size
through regulation of phosphorylation and activity of YAP, a transcription co-activator key for …

TAZ (transcriptional coactivator with PDZ-binding motif) and YAP (Yes-associated protein)
are key molecules of the Hippo pathway. Recent studies revealed that these molecules are …