Selectivity of a kinase inhibitor towards the target of interest is critical for its advancement
through the various phases of drug development. This makes kinase profiling of the inhibitor …

Selectivity of a kinase inhibitor towards the target of interest is critical for its advancement
through the various phases of drug development. This makes kinase profiling of the inhibitor …

Selectivity of a kinase inhibitor towards the target of interest is critical for its advancement
through the various phases of drug development. This makes kinase profiling of the inhibitor …

Drug safety is of paramount importance in the pharmaceutical industry indicating that
minimal side effects constitute a major requirement in drug development. Therefore, novel …

Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets.
The biological consequences of multi-kinase activity are poorly defined, and an important …

Over the past decade, a variety of technologies for the identification and characterization of
protein kinase inhibitors have been implemented in the laboratories of nearly every major …

SUMMARY GTCbio's Protein Kinase Inhibitor Design and Screening Meeting was one of six
co-located conferences at the Modern Drug Discovery and Development Summit, which …

Biochemical kinase profiling using a large panel of kinases with a broad coverage of the
human kinome has become the de facto norm within the Pharma industry. The importance of …

Understanding general selectivity trends across the kinome has implications ranging from
target selection, compound prioritization, toxicity and patient tailoring. Several recent …

The pivotal role of kinases in signal transduction and cellular regulation has lent them
considerable appeal as pharmacological targets across a broad spectrum of pathologies …