Regulation of cell proliferation and migration in glioblastoma: new therapeutic approach

Y Kim - Frontiers in oncology, 2013 - frontiersin.org
Glioblastoma is the most aggressive brain cancer with the poor survival rate. A microRNA,
miR-451, and its downstream molecules, CAB39/LKB1/STRAD/AMPK, are known to play a …

Role of extracellular matrix and microenvironment in regulation of tumor growth and LAR-mediated invasion in glioblastoma

Y Kim, H Kang, G Powathil, H Kim, D Trucu, W Lee… - PLoS …, 2018 - journals.plos.org
The cellular dispersion and therapeutic control of glioblastoma, the most aggressive type of
primary brain cancer, depends critically on the migration patterns after surgery and …

Strategies of eradicating glioma cells: A multi-scale mathematical model with miR-451-AMPK-mTOR control

Y Kim, G Powathil, H Kang, D Trucu, H Kim, S Lawler… - PloS one, 2015 - journals.plos.org
The cellular dispersion and therapeutic control of glioblastoma, the most aggressive type of
primary brain cancer, depends critically on the migration patterns after surgery and …

A hybrid model for cell proliferation and migration in glioblastoma

Y Kim, S Roh - Discrete and Continuous Dynamical Systems-B, 2013 - aimsciences.org
Glioblastoma is the most aggressive type of brain cancer with the median survival time of
one year. A particular microRNA, miR-451, and its counterpart, AMPK complex are known to …

Collective invasion of glioma cells through OCT1 signalling and interaction with reactive astrocytes after surgery

Y Kim, D Lee, S Lawler - Philosophical Transactions of …, 2020 - royalsocietypublishing.org
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer with a short
median survival time. GBM is characterized by the hallmarks of aggressive proliferation and …

miR451 and AMPK mutual antagonism in glioma cell migration and proliferation: a mathematical model

Y Kim, S Roh, S Lawler, A Friedman - PloS one, 2011 - journals.plos.org
Glioblastoma multiforme (GBM) is the most common and the most aggressive type of brain
cancer; the median survival time from the time of diagnosis is approximately one year. GBM …

Optimal control strategies of eradicating invisible glioblastoma cells after conventional surgery

AA de los Reyes V, E Jung… - Journal of The Royal …, 2015 - royalsocietypublishing.org
Glioblastoma, the most aggressive type of brain cancer, has median survival time of 1 year
after diagnosis. It is characterized by alternating modes of rapid proliferation and aggressive …

Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy

E Jung, AA de los Reyes V, KJA Pumares, Y Kim - PLoS One, 2019 - journals.plos.org
Glioblastoma multiforme is one of the most invasive type of glial tumors, which rapidly grows
and commonly spreads into nearby brain tissue. It is a devastating brain cancer that often …

Glioma cell migration and invasion as potential target for novel treatment strategies

U Naumann, P Harter, J Rubel, E Ilina… - Translational …, 2013 - degruyter.com
Diffuse human gliomas constitute a group of most treatment-refractory tumors even if
maximum treatment strategies including neurosurgical resection followed by combined radio …

Molecular mechanisms of glioma cell motility

A Armento, J Ehlers, S Schötterl… - Exon …, 2017 - exonpublications.com
Gliomas are the most common intracranial tumors in humans. The most malignant among
these tumors is glioblastoma (GBM), with an incidence of 3–5 out of 100,000 persons in …