Structure and function of TET enzymes
X Yin, L Hu, Y Xu - DNA Methyltransferases-Role and Function, 2022 - Springer
Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC).
TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine …
TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine …
Structure and function of TET enzymes
X Yin, Y Xu - DNA methyltransferases-role and function, 2016 - Springer
Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC).
TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine …
TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine …
Tet proteins: on track towards DNA demethylation?
N Véron - BioMolecular Concepts, 2012 - degruyter.com
Dynamic DNA methylation is a prerequisite for many developmental processes and
maintenance of cellular integrity. In mammals however, mechanisms of active DNA …
maintenance of cellular integrity. In mammals however, mechanisms of active DNA …
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
Ten-eleven translocation 1–3 (Tet1–3) proteins have recently been discovered in
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …
Tet family proteins and 5-hydroxymethylcytosine in development and disease
L Tan, YG Shi - Development, 2012 - journals.biologists.com
Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine,
5mC) has emerged as an important epigenetic modification that plays essential roles in …
5mC) has emerged as an important epigenetic modification that plays essential roles in …
Tet family of 5-methylcytosine dioxygenases in mammalian development
H Zhao, T Chen - Journal of human genetics, 2013 - nature.com
Methylation of cytosines is a major epigenetic modification in mammalian genomes. The
levels and patterns of DNA methylation are the results of the opposing actions of methylating …
levels and patterns of DNA methylation are the results of the opposing actions of methylating …
TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis
E Mahfoudhi, I Talhaoui, X Cabagnols, V Della Valle… - DNA repair, 2016 - Elsevier
Abstract The family of Ten-Eleven Translocation (TET) proteins is implicated in the process
of active DNA demethylation and thus in epigenetic regulation. TET 1, 2 and 3 proteins are …
of active DNA demethylation and thus in epigenetic regulation. TET 1, 2 and 3 proteins are …
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …
DNA elements, regulating transcription and establishing cellular identity. The recent …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Tet enzymes, variants, and differential effects on function
P Melamed, Y Yosefzon, C David… - Frontiers in cell and …, 2018 - frontiersin.org
Discovery of the ten-eleven translocation 1 (TET) methylcytosine dioxygenase family of
enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the …
enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the …