Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC).
TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine …

Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC).
TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine …

Dynamic DNA methylation is a prerequisite for many developmental processes and
maintenance of cellular integrity. In mammals however, mechanisms of active DNA …

Ten-eleven translocation 1–3 (Tet1–3) proteins have recently been discovered in
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …

Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine,
5mC) has emerged as an important epigenetic modification that plays essential roles in …

Methylation of cytosines is a major epigenetic modification in mammalian genomes. The
levels and patterns of DNA methylation are the results of the opposing actions of methylating …

Abstract The family of Ten-Eleven Translocation (TET) proteins is implicated in the process
of active DNA demethylation and thus in epigenetic regulation. TET 1, 2 and 3 proteins are …

In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Discovery of the ten-eleven translocation 1 (TET) methylcytosine dioxygenase family of
enzymes, nearly 10 years ago, heralded a major breakthrough in understanding the …