In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action
RJ Slack, VJ Barrett, VS Morrison, RG Sturton… - … of Pharmacology and …, 2013 - ASPET
Vilanterol trifenatate (vilanterol) is a novel, long-acting β 2-adrenoceptor (β 2-AR) agonist
with 24 h activity. In this study, we describe the preclinical pharmacological profile of …
with 24 h activity. In this study, we describe the preclinical pharmacological profile of …
Metabolism and disposition of vilanterol, a long-acting β2-adrenoceptor agonist for inhalation use in humans
AW Harrell, SK Siederer, J Bal, NH Patel… - Drug Metabolism and …, 2013 - ASPET
The metabolism and disposition of vilanterol, a novel long-acting β 2-adrenoceptor agonist
(LABA) for inhalation use, was investigated after oral administration in humans. Single oral …
(LABA) for inhalation use, was investigated after oral administration in humans. Single oral …
Vilanterol trifenatate, a novel inhaled long-acting beta2 adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in …
R Kempsford, V Norris, S Siederer - Pulmonary pharmacology & …, 2013 - Elsevier
Vilanterol (VI; GW642444M) is a novel inhaled long-acting β2-agonist with inherent 24 h
activity in vitro in development as a combination with the inhaled corticosteroid fluticasone …
activity in vitro in development as a combination with the inhaled corticosteroid fluticasone …
Pharmacological characterization of olodaterol, a novel inhaled β2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical models
T Bouyssou, P Casarosa, E Naline, S Pestel… - … of Pharmacology and …, 2010 - ASPET
The preclinical pharmacological profile of 6-hydroxy-8-[(1 R)-1-hydroxy-2-[[2-(4-
methoxyphenyl)-1, 1-dimethylethyl] amino] ethyl]-2 H-1, 4-benzoxazin-3 (4 H)-one …
methoxyphenyl)-1, 1-dimethylethyl] amino] ethyl]-2 H-1, 4-benzoxazin-3 (4 H)-one …
Pharmacological characterization of abediterol, a novel inhaled β2-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical …
M Aparici, M Gomez-Angelats, D Vilella, R Otal… - … of Pharmacology and …, 2012 - ASPET
Abediterol is a novel potent, long-acting inhaled β2-adrenoceptor agonist in development for
the treatment of asthma and chronic obstructive pulmonary disease. Abediterol shows …
the treatment of asthma and chronic obstructive pulmonary disease. Abediterol shows …
A cell-based assay to assess the persistence of action of agonists acting at recombinant human β2 adrenoceptors
S Summerhill, T Stroud, R Nagendra… - … of pharmacological and …, 2008 - Elsevier
INTRODUCTION: The aim was to establish a robust, 96-well, cell-based assay to assess the
potency and persistence of action of agonists acting at human recombinant β2 …
potency and persistence of action of agonists acting at human recombinant β2 …
Pharmacological basis for duration of effect: Formoterol and salmeterol versus short-acting β2-adrenoceptor agonists
A Linden, KF Rabe, CG Löfdahl - Lung, 1996 - Springer
The mechanisms behind the long duration of bronchodilating action of the β 2-adrenoceptor
agonists formoterol and salmeterol are only partially understood. This review compares …
agonists formoterol and salmeterol are only partially understood. This review compares …
Efficacy is a contributing factor to the clinical onset of bronchodilation of inhaled β2-adrenoceptor agonists
EM Rosethorne, RJ Turner, RA Fairhurst… - Naunyn-Schmiedeberg's …, 2010 - Springer
Inhaled β 2 adrenoceptor (β 2 AR) agonists are widely used as bronchodilator therapies for
asthma and COPD. Different agonists have varying rates of onset of action, eg indacaterol …
asthma and COPD. Different agonists have varying rates of onset of action, eg indacaterol …
Pharmacological characterization of indacaterol, a novel once daily inhaled β2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices
RG Sturton, A Trifilieff, AG Nicholson… - Journal of Pharmacology …, 2008 - ASPET
Indacaterol is a novel once daily inhaled β2 adrenoceptor agonist in clinical development.
This study compared the properties of indacaterol with salmeterol, formoterol, and albuterol …
This study compared the properties of indacaterol with salmeterol, formoterol, and albuterol …
Why are long-acting beta-adrenoceptor agonists long-acting?
GP Anderson, A Linden, KF Rabe - European Respiratory …, 1994 - Eur Respiratory Soc
The extended duration of bronchodilation due to formoterol and salmeterol greatly exceeds
that of short acting beta 2-adrenoceptor agonists, such as salbutamol or terbutaline. This …
that of short acting beta 2-adrenoceptor agonists, such as salbutamol or terbutaline. This …