Neuroprotection in glaucoma: recent advances and clinical translation

C Guymer, JPM Wood, G Chidlow… - Clinical & …, 2019 - Wiley Online Library
Intraocular pressure (IOP) reduction is currently the only evidence‐based treatment strategy
for glaucoma. However, IOP control in some individuals is challenging. Despite optimal …

A review of potential novel glaucoma therapeutic options independent of intraocular pressure

WS Shalaby, OM Ahmed, M Waisbourd, LJ Katz - Survey of Ophthalmology, 2022 - Elsevier
Glaucoma, a progressive optic neuropathy characterized by retinal ganglion cell
degeneration and visual field loss, is the leading cause of irreversible blindness worldwide …

Neuroprotection in glaucoma: basic aspects and clinical relevance

CY Kuo, CJL Liu - Journal of Personalized Medicine, 2022 - mdpi.com
Glaucoma is a neurodegenerative disease that affects primarily the retinal ganglion cells
(RGCs). Increased intraocular pressure (IOP) is one of the major risk factors for glaucoma …

Neuroprotection in glaucoma: towards clinical trials and precision medicine

TZ Khatib, KR Martin - Current Eye Research, 2020 - Taylor & Francis
Purpose: The eye is currently at the forefront of translational medicine and therapeutics.
However, despite advances in technology, primary open-angle glaucoma remains the …

Current perspective of neuroprotection and glaucoma

K Tian, S Shibata-Germanos, M Pahlitzsch… - Clinical …, 2015 - Taylor & Francis
Glaucoma is the second leading cause of blindness worldwide and is most notably
characterized by progressive optic nerve atrophy and advancing loss of retinal ganglion …

Translational neuroprotection research in glaucoma: a review of definitions and principles

RJ Casson, G Chidlow, A Ebneter… - Clinical & …, 2012 - Wiley Online Library
The maintenance of vision, through prevention and attenuation of neuronal injury in
glaucoma, forms the basis of current clinical practice. Currently, the reduction of intraocular …

[HTML][HTML] Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering

JR Tribble, F Hui, H Quintero, S El Hajji, K Bell… - Molecular aspects of …, 2023 - Elsevier
Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Challenges in the development of glaucoma neuroprotection therapy

Y Liu, IH Pang - Cell and tissue research, 2013 - Springer
Glaucoma, a disease of the optic nerve and retina, causes blindness in millions of people
worldwide. Currently available therapies for this disease only attempt to reduce intraocular …

Current medical therapy and future trends in the management of glaucoma treatment

B Cvenkel, M Kolko - Journal of Ophthalmology, 2020 - Wiley Online Library
Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal
ganglion cells and their axons. Lowering of intraocular pressure (IOP) is currently the only …

Neuroprotective strategies in glaucoma

CA Gossman, J Christie, MK Webster… - Current …, 2016 - ingentaconnect.com
Background: Glaucoma is characterized as a neuropathic disease that causes progressive
degeneration of retinal ganglion cells (RGCs) in the retina, resulting in irreversible loss of …