Bio-tactics for neuroprotection of retinal ganglion cells in the treatment of glaucoma

KS Yadav, S Sharma, VY Londhe - Life sciences, 2020 - Elsevier
Glaucoma, a neurodegenerative disorder is characterized by damage of ganglion cells of
retina and also its axons. The manner of progression of disease and retinal ganglion cells …

Current and emerging medical therapies for glaucoma

JC Tsai, EM Kanner - Expert opinion on emerging drugs, 2005 - Taylor & Francis
Glaucoma is a multifactorial optic neuropathy in which there is a characteristic acquired loss
of retinal ganglion cells, at levels beyond normal age-related baseline loss, and …

Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse

J Zhang, L Li, H Huang, F Fang, HC Webber, P Zhuang… - Elife, 2019 - elifesciences.org
Understanding the molecular mechanism of glaucoma and development of neuroprotectants
is significantly hindered by the lack of a reliable animal model that accurately recapitulates …

Normal-tension glaucoma: is it different from primary open-angle glaucoma?

MB Shields - Current opinion in ophthalmology, 2008 - journals.lww.com
In clinical practice, control of IOP remains the mainstay of managing NTG patients, but
consideration must also be given to other factors, especially those that may influence …

Targeting diet and exercise for neuroprotection and neurorecovery in glaucoma

JR Tribble, F Hui, M Jöe, K Bell, V Chrysostomou… - Cells, 2021 - mdpi.com
Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive
dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual …

Glaucomatous optic neuropathy treatment options: the promise of novel therapeutics, techniques and tools to help preserve vision

NA Sharif - Neural regeneration research, 2018 - journals.lww.com
Peripheral vision loss followed by “tunnel vision” and eventual irreversible blindness is the
fate of patients afflicted by various forms of glaucoma including primary open-angle …

Towards a microbead occlusion model of glaucoma for a non-human primate

WS Lambert, BJ Carlson, P Ghose, VD Vest, V Yao… - Scientific Reports, 2019 - nature.com
Glaucoma is a group of optic neuropathies associated with aging and sensitivity to
intraocular pressure (IOP). The disease causes vision loss through the degeneration of …

Neuroprotection of medical IOP-lowering therapy

N Pfeiffer, J Lamparter, A Gericke, FH Grus… - Cell and tissue …, 2013 - Springer
Intraocular pressure (IOP)-lowering therapy has been shown to arrest or retard the
progression of optic neuropathy typical for glaucoma and can, thus, be described as …

How does lowering of intraocular pressure protect the optic nerve?

P Mackenzie, G Cioffi - Survey of ophthalmology, 2008 - Elsevier
Until recently, the evidence that lowering intraocular pressure (IOP) protects the optic nerve
from glaucomatous damage was weak. Several randomized controlled trials have provided …

Neuroprotection in optic neuropathy

LA Levin - The Asia-Pacific Journal of Ophthalmology, 2018 - journals.lww.com
Almost all optic neuropathies are untreatable, motivating the search for new therapies that
address the final common pathway of optic nerve disease, retinal ganglion cell loss. These …