Long noncoding RNAs (lncRNAs) are emerging as key regulators of crucial cellular
processes. However, the molecular mechanisms of many lncRNA functions remain …

The SOX proteins belong to the superfamily of transcription factors (TFs) that display
properties of both classical TFs and architectural components of chromatin. Since the …

The transcription factor Sox2 controls the fate of pluripotent stem cells and neural stem cells.
This gatekeeper function requires well-regulated Sox2 levels. We postulated that Sox2 …

The Sox2 gene is a key regulator of pluripotency embedded within an intron of a long
noncoding RNA (ncRNA), termed Sox2 overlapping transcript (Sox2ot), which is transcribed …

ABSTRACT SOX1 is a member of the SOXB1 subgroup of transcription factors involved in
early embryogenesis, CNS development and maintenance of neural stem cells. The …

Long noncoding RNAs (lncRNAs) are abundant in the mammalian transcriptome, and many
are specifically expressed in the brain. We have identified a group of lncRNAs, including …

The mammalian neocortex is established from neural stem and progenitor cells that utilize
specific transcriptional and environmental factors to create functional neurons and …

The transcription factor SOX3 is expressed within most neural progenitor (NP) cells of the
vertebrate central nervous system (CNS) and is essential for normal brain development in …

Neural stem/progenitor cells maintain their identity via continuous self-renewal and
suppression of differentiation. Gain-of-function experiments in the chick revealed an …

The transcription factor Sox2 is expressed at high levels in neural stem and progenitor cells.
Here, we inactivated Sox2 specifically in the developing brain by using Cre–loxP system …