Macrophage Proliferation Machinery Drives Immunosuppression and PDAC Progression (巨噬细胞增值机制抑制肿瘤免疫促进胰腺癌发展)

C Zuo - 2022 - openscholarship.wustl.edu
Tumor-associated macrophages (TAMs) are abundant in near all solid tumors and are
involved in many aspects of cancer progression. The presence of TAMs is negative …

A Thesis on Macrophage Proliferation Machinery Drives Immunosuppression and PDAC Progression

C Zuo - 2022 - search.proquest.com
Tumor-associated macrophages (TAMs) are abundant in near all solid tumors and are
involved in many aspects of cancer progression. The presence of TAMs is negative …

Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

C Zuo, JM Baer, BL Knolhoff, JI Belle, X Liu… - Journal of Experimental …, 2023 - rupress.org
Tumor-associated macrophages (TAMs) are abundant in pancreatic ductal
adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the …

Macrophages and pancreatic ductal adenocarcinoma

A Habtezion, M Edderkaoui, SJ Pandol - Cancer letters, 2016 - Elsevier
Monocytes and macrophages make up part of the innate immune system and provide one of
the first defenses against variety of treats. Macrophages can also modulate the adaptive …

Macrophage proliferation machinery leads to PDAC progression, but susceptibility to innate immunotherapy

C Zuo, JM Baer, BL Knolhoff, JI Belle, X Liu, GD Hogg… - bioRxiv, 2021 - biorxiv.org
Tumor-associated macrophages (TAMs) are involved in many aspects of cancer progression
and correlate with poor clinical outcomes in many cancer types, including pancreatic ductal …

[HTML][HTML] Impact of tumour associated macrophages in pancreatic cancer

A Mielgo, MC Schmid - BMB reports, 2013 - ncbi.nlm.nih.gov
During cancer progression, bone marrow derived myeloid cells, including immature myeloid
cells and macrophages, progressively accumulate at the primary tumour site where they …

[PDF][PDF] Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression

Y Zhu, JM Herndon, DK Sojka, KW Kim, BL Knolhoff… - Immunity, 2017 - cell.com
Tumor-associated macrophages (TAMs) are essential components of the cancer
microenvironment and play critical roles in the regulation of tumor progression. Optimal …

[HTML][HTML] Role of tumor associated macrophages in regulating pancreatic cancer progression

R Caso, G Miller - World Journal of Immunology, 2016 - wjgnet.com
Pancreatic cancer has an overall 5-year survival rate of less than 5%. Unfortunately, patient
survival has not substantially improved in the last couple of decades despite advances in …

[HTML][HTML] Tumor-associated macrophages in pancreatic ductal adenocarcinoma: origin, polarization, function, and reprogramming

S Yang, Q Liu, Q Liao - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy. PDAC is only
cured by surgical resection in its early stage, but there remains a relatively high possibility of …

Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy

G Di Caro, N Cortese, GF Castino, F Grizzi, F Gavazzi… - Gut, 2016 - gut.bmj.com
Objective Tumour-associated macrophages (TAMs) play key roles in tumour progression.
Recent evidence suggests that TAMs critically modulate the efficacy of anticancer therapies …