Background Low-density lipoprotein (LDL) receptor is normally regulated via a feedback
system that is dependent on intracellular cholesterol levels. We have demonstrated that …

Objective To investigate if inflammatory stress increases intracellular accumulation of
unmodified low-density lipoprotein (LDL) in human monocyte cell line (THP-1) macrophages …

LDL receptor (LDLr) is widely expressed in both liver and peripheral tissue. We aimed to
clarify tissue-specific regulation of LDLr in hepatic cell line (HepG2) cells and human kidney …

The aim of this article is to investigate whether interleukin-1β (IL-1β) could regulate the
intracellular accumulation of cholesterol and the expression of lipid-metabolism-related …

The low-density lipoprotein receptor (LDLR) pathway is a negative feedback system that
plays important roles in the regulation of plasma and intracellular cholesterol homeostasis …

As a daily supplement, omega‑3 fatty acid is confirmed to be of benefit in
hypertriglyceridemia. However, the effect of omega‑3 fatty acids on the low‑density …

Recent therapeutic strategies for the treatment of familial hypercholesterolemia have been
based on liver-directed gene transfer of a functional low-density lipoprotein (LDL) receptor …

The prevailing theory in non‐alcoholic fatty liver disease (NAFLD) is the “two‐hit”
hypothesis. The first hit mainly consists of lipid accumulation, and the second is subsequent …

Low-density lipoproteins (LDL) are taken up by both LDL receptor (LDLr)-dependent and-
independent pathways. In order to determine the importance of these pathways in the …

Oxidized low‑density lipoprotein (LDL) has an important role in atherogenesis; however, the
mechanisms underlying cell‑mediated LDL oxidation remain to be elucidated. The present …