阿尔茨海默病(Alzheimer's disease, AD) 是一种神经退行性疾病, 为老年痴呆症的主要形式之一.
tau 蛋白为一种微管相关蛋白, 其过度磷酸化在AD 的发病过程中起着关键作用 …

Although hyperphosphorylated tau is an established feature of Alzheimer's Disease, its role
in the disease process is poorly understood, partly because of lack of suitable animal …

Alzheimer's disease (AD) is a heterogeneous dementing disorder of the elderly that is
characterized by progressive cognitive impairments and the accumulation of abundant …

The microtubule-associated protein tau, which is abundantly expressed in neurons, is
deposited in cells in an abnormally phosphorylated state as fibrillar lesions in numerous …

Background Tau‐induced synaptic dysfunction is thought to play a key role in the memory
decline of Alzheimer's disease (AD). Synapses are complex multicomponent structures that …

阿尔茨海默病中Tau蛋白和Aβ相互作用的研究进展-[维普官方网站]-www.cqvip.com-维普网  我的
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Clinical studies suggest that depression could be considered an important risk factor for the
future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a …

Hyperphosphorylation of the microtubule-associated protein tau and its resultant
aggregation into neurofibrillary tangles (NFT) is a pathological characteristic of …

It is well-known that some kinases which are involved in the induction of synaptic plasticity
probably modulate tau phosphorylation. However, how depression of potentiated synaptic …

Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptide (Aβ)
and hyperphosphorylated Tau protein (P-Tau). Our recent data showed a differential …