Dlk1 and Gtl2 are reciprocally expressed imprinted genes located on mouse chromosome
12. The Dlk1–Gtl2 locus carries three differentially methylated regions (DMRs), which are …

The monoallelic expression of imprinted genes is controlled by epigenetic factors including
DNA methylation and histone modifications. In mouse, the imprinted gene Gtl2 is associated …

The insulin-like growth factor 2 gene (IGF2) encodes an essential growth factor and is
imprinted in various mammalian species. Differentially methylated regions (DMRs) are often …

Genomic imprinting of the Cdkn1c/Kcnq1ot1 region shows lack of conservation between
human and mouse. This region has been reported to be associated with Beckwith …

Mice with maternal duplication of proximal chromosome 6 die in utero at an early embryonic
stage. Recently, two imprinted genes, paternally expressed Sgce and maternally expressed …

Abstract Background Beckwith-Wiedemann syndrome (BWS) is a loss-of-imprinting pediatric
overgrowth syndrome. The primary features of BWS include macrosomia, macroglossia, and …

Contents Genomic imprinting and DNA methylation play an important role in mammalian
development. Many cloned animals showed heterogeneous DNA methylation profiles …

Genomic imprinting is theorized to exist in all placental mammals and some marsupials;
however, extensive comparative analysis of animals aside from humans and mice remains …

Insulin-like growth factor II (IGF2) and H19 genes are mutually imprinted genes which may
be responsible for abnormalities in the cloned fetuses and offspring. This study was …

In this study we describe a modification of the bisulfite genomic sequencing protocol that
enables detection of methylation from as few as five diploid cells from preimplantation …