Although the role of aromatase in many estrogen-dependent reproductive and metabolic
functions is well documented in vertebrates, its involvement in the ovarian development of …

It has been hypothesized that estrogen production may play a pivotal role in the sex
determination of reptiles with temperature-dependent sex determination (TSD). This …

In the red-eared slider turtle (Trachemys scripta), a species with temperature-dependent sex
determination (TSD), the expression of the aromatase gene during gonad development is …

The developmental processes underlying gonadal differentiation are conserved across
vertebrates, but the triggers initiating these trajectories are extremely variable. The red …

Gonadal sex in the red-eared slider turtle is determined by the incubation temperature that
the embryo experiences during the mid-trimester of development. High temperatures result …

The formation of estrogens from androgens in all vertebrates is catalyzed by the “aromatase”
complex, which consists of a membrane bound P450 enzyme, P450 aromatase (which binds …

Steroid hormones affect sex determination in a variety of vertebrates. The feminizing effects
of exposure to estradiol and the masculinizing effects of aromatase inhibition during …

The environment surrounding the embryos has a profound impact on the developmental
process and phenotypic outcomes of the organism. In species with temperature-dependent …

Many data suggest an involvement of estrogens in gonadal differentiation in reptiles with
temperature-dependent sex determination (TSD). However, the site of estrogen synthesis in …

A brief review of our current understanding (or lack of understanding) of the molecular basis
of temperature‐dependent sex determination (TSD) in reptiles is presented. Current theories …