Embryological ontogeny of aromatase gene expression in Chrysemys picta and Apalone mutica turtles: comparative patterns within and across temperature …

N Valenzuela, T Shikano - Development genes and evolution, 2007 - Springer
Although the role of aromatase in many estrogen-dependent reproductive and metabolic
functions is well documented in vertebrates, its involvement in the ovarian development of …

Cloning and expression of aromatase in a turtle with temperature-dependent sex determination

C Murdock, T Wibbels - General and comparative endocrinology, 2003 - Elsevier
It has been hypothesized that estrogen production may play a pivotal role in the sex
determination of reptiles with temperature-dependent sex determination (TSD). This …

[HTML][HTML] Epigenetic Control of Gonadal Aromatase (cyp19a1) in Temperature-Dependent Sex Determination of Red-Eared Slider Turtles

Y Matsumoto, A Buemio, R Chu, M Vafaee, D Crews - PLoS One, 2013 - journals.plos.org
In the red-eared slider turtle (Trachemys scripta), a species with temperature-dependent sex
determination (TSD), the expression of the aromatase gene during gonad development is …

Steroid signaling and temperature-dependent sex determination—Reviewing the evidence for early action of estrogen during ovarian determination in turtles

M Ramsey, D Crews - Seminars in cell & developmental biology, 2009 - Elsevier
The developmental processes underlying gonadal differentiation are conserved across
vertebrates, but the triggers initiating these trajectories are extremely variable. The red …

Aromatase activity during embryogenesis in the brain and adrenal–kidney–gonad of the red-eared slider turtle, a species with temperature-dependent sex …

E Willingham, R Baldwin, JK Skipper… - General and Comparative …, 2000 - Elsevier
Gonadal sex in the red-eared slider turtle is determined by the incubation temperature that
the embryo experiences during the mid-trimester of development. High temperatures result …

Expression of P450arom in Malaclemys terrapin and Chelydra serpentina: A tale of two sites

AR Place, J Lang, S Gavasso… - Journal of Experimental …, 2001 - Wiley Online Library
The formation of estrogens from androgens in all vertebrates is catalyzed by the “aromatase”
complex, which consists of a membrane bound P450 enzyme, P450 aromatase (which binds …

Exogenous application of estradiol to eggs unexpectedly induces male development in two turtle species with temperature-dependent sex determination

DA Warner, E Addis, W Du, T Wibbels… - General and comparative …, 2014 - Elsevier
Steroid hormones affect sex determination in a variety of vertebrates. The feminizing effects
of exposure to estradiol and the masculinizing effects of aromatase inhibition during …

[HTML][HTML] Temperature Shift Alters DNA Methylation and Histone Modification Patterns in Gonadal Aromatase (cyp19a1) Gene in Species with Temperature-Dependent …

Y Matsumoto, B Hannigan, D Crews - PLoS One, 2016 - journals.plos.org
The environment surrounding the embryos has a profound impact on the developmental
process and phenotypic outcomes of the organism. In species with temperature-dependent …

Sensitive stages for the effects of temperature on gonadal aromatase activity in embryos of the marine turtle Dermochelys coriacea

G Desvages, M Girondot, C Pieau - General and comparative …, 1993 - Elsevier
Many data suggest an involvement of estrogens in gonadal differentiation in reptiles with
temperature-dependent sex determination (TSD). However, the site of estrogen synthesis in …

Is regulation of aromatase expression in reptiles the key to understanding temperature‐dependent sex determination?

VA Lance - Journal of Experimental Zoology Part A: Ecological …, 2009 - Wiley Online Library
A brief review of our current understanding (or lack of understanding) of the molecular basis
of temperature‐dependent sex determination (TSD) in reptiles is presented. Current theories …