Objective To investigate the specific induction of cytotoxic lymphocyte (CTL) by tumor-
derived heat shock protein 90-peptide complexes (HSP90-PC). Methods Heat shock protein …

In the current study, exposure of mammary tumor cells derived from mice transgenic for the
polyomavirus middle T oncogene to ionizing radiation resulted in the generation of a tumor …

Antigenic cross‐reactivity between certain tumours has allowed the development of more
widely applicable, major histocompatibility complex‐disparate (allogeneic) whole‐cell …

One of the major hurdles facing cancer immunotherapy is that cancers may downregulate
expression of MHC class I molecules. The development of a suitable tumor model with …

Although being promising tumor vaccine candidates in animal models, heat shock protein
(HSP)-based tumor vaccines have not yet succeeded in the clinical trials, implying the …

We have studied the effects of recombinant adenoviruses as immune adjuvants for DNA
vaccination. In a mouse model, using the weak immunogen carcinoembryonic antigen …

Objective: To determine the adjuvant activity of recombinant human HSP70D protein.
Methods: Dendritic cells were cultured in vitro, rhHSP70D was added into the culture …

The eukaryotic expression plasmid of M2e-Hsp70 is a candidate M2e-based DNA vaccine.
In order to evaluate the immunization potential of this construct, Specific Pathogen Free …

The injection of naked plasmid DNA directly into the muscle cells of hosts has been shown
to induce potent immune responses, as well as to express large amounts of gene product; …