Tumor immunotherapy has exploited the ability of heat shock proteins to chaperone
precursors of antigenic peptides to antigen-presenting cells and to activate efficiently an …

Biologic tumor therapy using Interleukin-12 (IL-12) has shown promise as an adjuvant to
radiation therapy. The goals for cancer gene immunotherapy include effective eradication of …

Objective To construct a replicative anti-tumor DNA vaccine PSCK-2PFcGB based on
Semliki Forest Virus (SFV) replicon vector and observe its expression in vivo and in vitro …

Tumor cell-derived heat shock proteins (Hsps) such as gp96 have been used as vaccines
for immunotherapy of cancer patients. However, current approaches for immunotherapy are …

DNA vaccines have emerged as an attractive approach for antigen-specific cancer
immunotherapy. We have previously linked Mycobacterium tuberculosis heat shock protein …

Several studies have suggested a positive correlation between heat shock protein (hsp)
expression and tumor immunogenicity. Independently, many studies have shown that hsp …

A novel membrane-bound heat shock protein 70 (mbHSP70) was expressed on the surface
of the mouse mastocytoma cell line P815 to enhance immunogenicity of tumor cells. The in …

Melanoma antigen-encoding gene 3 (MAGE-3) is an ideal candidate for a tumor vaccine
although its potency need to be increased. Heat shock proteins (HSPs) represents a …

Our pre-clinical studies demonstrated that intratumoral vaccination with a recombinant
oncolytic type 2 adenovirus overexpressing the heat shock protein (HSP) 70 protein …

Recently, we reported that heat shock protein 105 (HSP105) DNA vaccination induced anti-
tumor immunity. In this study, we set up a preclinical study to investigate the usefulness of …