Monogenic diabetes: genetics and relevance on diabetes mellitus personalized medicine

M Sousa, J Bruges-Armas - Current diabetes reviews, 2020 - ingentaconnect.com
Background: Diabetes mellitus (DM) is a complex disease with significant impression in
today's world. Aside from the most common types recognized over the years, such as type 1 …

Monogenic diabetes

A Bonnefond, R Unnikrishnan, A Doria… - Nature Reviews …, 2023 - nature.com
Monogenic diabetes includes several clinical conditions generally characterized by early-
onset diabetes, such as neonatal diabetes, maturity-onset diabetes of the young (MODY) …

[HTML][HTML] Insight on diagnosis and treatment from over a decade of research through the University of Chicago Monogenic Diabetes Registry

TL Bowden, LR Letourneau-Freiberg… - Frontiers in clinical …, 2021 - frontiersin.org
Monogenic diabetes is a category of diabetes mellitus caused by a single gene mutation or
chromosomal abnormality, usually sub-classified as either neonatal diabetes or maturity …

How recent advances in genomics improve precision diagnosis and personalized care of maturity-onset diabetes of the young

M Vaxillaire, P Froguel, A Bonnefond - Current Diabetes Reports, 2019 - Springer
Abstract Purpose of Review Non-autoimmune monogenic diabetes (MD) in young people
shows a broad spectrum of clinical presentations, which is largely explained by multiple …

Many faces of monogenic diabetes

VM Schwitzgebel - Journal of diabetes investigation, 2014 - Wiley Online Library
Monogenic diabetes represents a heterogeneous group of disorders resulting from defects
in single genes. Defects are categorized primarily into two groups: disruption of β‐cell …

Monogenic Diabetes: From Genetic Insights to Population-Based Precision in Care. Reflections From a Diabetes Care Editors' Expert Forum

MC Riddle, LH Philipson, SS Rich, A Carlsson… - Diabetes …, 2020 - Am Diabetes Assoc
Individualization of therapy based on a person's specific type of diabetes is one key element
of a “precision medicine” approach to diabetes care. However, applying such an approach …

Monogenic models: what have the single gene disorders taught us?

T Klupa, J Skupien, MT Malecki - Current Diabetes Reports, 2012 - Springer
Monogenic diabetes constitutes a heterogeneous group of single gene disorders. The
molecular background and clinical picture of many of these diseases have been described …

Monogenic childhood diabetes: dissecting clinical heterogeneity by next-generation sequencing in maturity-onset diabetes of the young

DK Demirci, F Darendeliler, S Poyrazoglu… - OMICS: A Journal of …, 2021 - liebertpub.com
Diabetes is a common disorder with a heterogeneous clinical presentation and an
enormous burden on health care worldwide. About 1–6% of patients with diabetes suffer …

Monogenic diabetes clinic (MDC): 3-year experience

N Rapini, PI Patera, R Schiaffini, P Ciampalini… - Acta Diabetologica, 2023 - Springer
Aim In the pediatric diabetes clinic, patients with type 1 diabetes mellitus (T1D) account for
more than 90% of cases, while monogenic forms represent about 6%. Many monogenic …

[HTML][HTML] Genetic perspectives on childhood monogenic diabetes: Diagnosis, management, and future directions

HY Sun, XY Lin - World Journal of Diabetes, 2023 - ncbi.nlm.nih.gov
Monogenic diabetes is caused by one or even more genetic variations, which may be
uncommon yet have a significant influence and cause diabetes at an early age. Monogenic …