Background: Monogenic diabetes is a group of disorders caused by mutations in any one of
a number of genes. Although a monogenic diagnosis—estimated to represent as much as …

Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic
causes of beta-cell dysfunction and diabetes arising in children and young adults. Making …

Most diabetes is polygenic in etiology, with (type 1 diabetes, T1DM) or without (type 2
diabetes, T2DM) an autoimmune basis. Genetic counseling for diabetes generally focuses …

At present, outside of infancy, genetic testing for monogenic diabetes is typically for
mutations in maturity-onset diabetes of the young (MODY) genes that predominantly result in …

Background Monogenic diabetes presents opportunities for precision medicine but is
underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria …

Aims/hypothesis Current clinical guidelines for childhood-onset monogenic diabetes outside
infancy are mainly focused on identifying and testing for dominantly inherited, predominantly …

Monogenic diabetes is estimated to account for 0.5-1.2% of all diabetes cases and remains
underdiagnosed. It consists of a variety of subtypes associated with mutations in more than …

Abstract Aims/Introduction Monogenic diabetes accounts for approximately 1–2% of all
diabetes, and is difficult to distinguish from type 1 and type 2 diabetes. Molecular diagnosis …

Individual predisposition to type 2 diabetes is influenced by the combined effect of a
constellation of genetic variants and a multitude of environmental exposures. Identification of …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive or non-Mendelian trait or may present as a …