[HTML][HTML] 血管平滑肌SCAP 过表达抑制自噬促进脂质积聚的机制研究
饶雨涵， 李丹阳， 侯晓俐， 姚盈程， 苏玉， 陈压西… - 2022 - aammt.tmmu.edu.cn
目的探讨固醇调节元件结合蛋白裂解活化蛋白(sterol regulatory element binding proteins
cleavage activating protein, SCAP) 对血管平滑肌细胞(vascular smooth muscle cells …
cleavage activating protein, SCAP) 对血管平滑肌细胞(vascular smooth muscle cells …
SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE (-/-) mice
D Li, A Chen, T Lan, Y Zou, L Zhao, P Yang… - FASEB …, 2019 - discovery.ucl.ac.uk
Sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) is a
cholesterol sensor that plays a critical role in regulating intracellular cholesterol levels, but …
cholesterol sensor that plays a critical role in regulating intracellular cholesterol levels, but …
SCAP/SREBP2/LDLr 通路在LPS 诱导人血管平滑肌细胞泡沫化中的作用
叶强， 雷寒， 范忠才， 郑文武， 郑舒展 - 泸州医学院学报, 2014 - cqvip.com
目的: 研究炎症介质——脂多糖(LPS) 是否通过扰乱固醇调节元件结合蛋白裂解激活蛋白-
固醇调节元件结合蛋白2 (SCAP-SREBP2) 复合物介导的低密度脂蛋白受体(LDLr) 负反馈调控 …
固醇调节元件结合蛋白2 (SCAP-SREBP2) 复合物介导的低密度脂蛋白受体(LDLr) 负反馈调控 …
炎症诱导SCAP 功能失调促进ApoE^(-/-) 小鼠动脉粥样硬化的分子机制
周超， 季新忠， 刘巧， 伍莎莎， 欧阳南 - 第三军医大学学报, 2016 - cqvip.com
目的探讨炎症诱导胆固醇调节元件结合蛋白裂解激活蛋白(sterol regulatory element binding
proteins cleavage-activating protein, SCAP) 功能失调促进ApoE~(-/-) 小鼠动脉粥样硬化形成 …
proteins cleavage-activating protein, SCAP) 功能失调促进ApoE~(-/-) 小鼠动脉粥样硬化形成 …
Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation
C Zhou, H Lei, Y Chen, Q Liu, LC Li, JF Moorhead… - PLoS …, 2013 - journals.plos.org
Inflammatory stress promotes foam cell formation by disrupting LDL receptor feedback
regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) …
regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) …
[HTML][HTML] 胆固醇敏感器SCAP 功能失调通过上调P2X7 受体表达促进THP-1 源性巨噬细胞炎症小体活化
伍莎莎， 欧阳南， 何泉， 周超 - 2017 - aammt.tmmu.edu.cn
目的探讨胆固醇调节原件结合蛋白裂解激活蛋白(sterol regulatory element binding proteins
cleavage-activating protein, SCAP) 功能失调促进THP-1 源性巨噬细胞炎症小体活化及IL-1β …
cleavage-activating protein, SCAP) 功能失调促进THP-1 源性巨噬细胞炎症小体活化及IL-1β …
Dysfunction of cholesterol sensor SCAP promotes inflammation activation in THP-1 macrophages
N Ouyang, H Gan, Q He, H Lei, SY Wang, Q Liu… - Experimental Cell …, 2018 - Elsevier
Crosstalk occurs between dyslipidemia and chronic inflammation, which are both
precipitants of atherosclerosis. Sterol regulatory element binding proteins cleavage …
precipitants of atherosclerosis. Sterol regulatory element binding proteins cleavage …
胆固醇敏感器SCAP 功能失调对THP-1 源性巨噬细胞炎症因子表达的影响
欧阳南， 杜晓刚， 陈利群， 周超 - 第三军医大学学报, 2016 - cqvip.com
目的观察胆固醇调节元件结合蛋白裂解激活蛋白(sterol regulatory element binding proteins
cleavage-activating protein, SCAP) 功能失调对THP-1 源性巨噬细胞脂质代谢及IL-1β, MCP-1 …
cleavage-activating protein, SCAP) 功能失调对THP-1 源性巨噬细胞脂质代谢及IL-1β, MCP-1 …
炎症促进清道夫受体基因敲除小鼠主动脉脂质积聚的分子机制
刘宏， 柳青， 雷寒， 李秀兰， 陈显 - 第三军医大学学报, 2010 - cqvip.com
目的探讨炎症促进清道夫受体A 和CD36 双敲(SR double knockout, SRDKO) C57BL/6J
小鼠主动脉固醇调节元件结合蛋白2 (sterol regulatory element binding protein2, SREBP2) …
小鼠主动脉固醇调节元件结合蛋白2 (sterol regulatory element binding protein2, SREBP2) …
[HTML][HTML] Sterol-resistant SCAP overexpression in vascular smooth muscle cells accelerates atherosclerosis by increasing local vascular inflammation through …
D Li, M Liu, Z Li, G Zheng, A Chen, L Zhao… - Aging and …, 2021 - ncbi.nlm.nih.gov
Atherosclerosis is a serious age-related pathology, and one of its hallmarks is the presence
of chronic inflammation. Sterol regulatory element-binding protein (SREBP) cleavage …
of chronic inflammation. Sterol regulatory element-binding protein (SREBP) cleavage …