Enhanced immunity by NeuEDhsp70 DNA vaccine is needed to combat an aggressive spontaneous metastatic breast cancer
JH Kim, N Majumder, H Lin, J Chen, LD Falo, Z You - Molecular Therapy, 2005 - cell.com
The rapid growth and ruthless metastasis of tumors demand effective broad immune
responses. Dendritic cells (DCs) are critical in developing tumor vaccines. Recent …
responses. Dendritic cells (DCs) are critical in developing tumor vaccines. Recent …
Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma
D Toomey, H Conroy, AG Jarnicki, SC Higgins… - Vaccine, 2008 - Elsevier
Prophylactic immunization of mice with autologous tumor-derived heat shock proteins (Hsp)
generates effective anti-tumor immunity. However, this approach is ineffective when used …
generates effective anti-tumor immunity. However, this approach is ineffective when used …
Generation of anti-tumor immunity using mammalian heat shock protein 70 DNA vaccines for cancer immunotherapy
Y Li, J Subjeck, G Yang, E Repasky, XY Wang - Vaccine, 2006 - Elsevier
In this study, we explored the protective anti-tumor potency of mouse (self) Hsp70 or Hsp110-
based DNA vaccination approach targeting a tumor-associated antigen, human papilloma …
based DNA vaccination approach targeting a tumor-associated antigen, human papilloma …
Enhanced T-cell immunity induced by dendritic cells with phagocytosis of heat shock protein 70 gene-transfected tumor cells in early phase of apoptosis
The dual role of heat shock protein 70 (HSP70), as antigenic peptide chaperone and danger
signal, makes it especially important in dendritic cell (DC)-based vaccination. In this study …
signal, makes it especially important in dendritic cell (DC)-based vaccination. In this study …
[HTML][HTML] N-terminally fusion of Her2/neu to HSP70 decreases efficiency of Her2/neu DNA vaccine
DNA vaccines consisted of tumor-associated antigen (TAA) are well suited for
immunotherapy against tumor. The construct can contain TAA fused to an appropriate …
immunotherapy against tumor. The construct can contain TAA fused to an appropriate …
Immunization with heat shock protein 105-pulsed dendritic cells leads to tumor rejection in mice
K Yokomine, T Nakatsura, M Minohara, J Kira… - Biochemical and …, 2006 - Elsevier
Recently, we reported that heat shock protein 105 (HSP105) DNA vaccination induced anti-
tumor immunity. In this study, we set up a preclinical study to investigate the usefulness of …
tumor immunity. In this study, we set up a preclinical study to investigate the usefulness of …
Induction of ErbB-2/neu-specific protective and therapeutic antitumor immunity using genetically modified dendritic cells: enhanced efficacy by cotransduction of gene …
Overexpression of ErbB-2/neu occurs in 20–30% of patients with breast cancer and
indicates a poor prognosis. The presence of a detectable immune response to ErbB-2/neu in …
indicates a poor prognosis. The presence of a detectable immune response to ErbB-2/neu in …
Chicken HSP70 DNA vaccine inhibits tumor growth in a canine cancer model
WY Yu, TF Chuang, C Guichard, H El-Garch, D Tierny… - Vaccine, 2011 - Elsevier
Immunization with xenogeneic DNA is a promising cancer treatment to overcome tolerance
to self-antigens. Heat shock protein 70 (HSP70) is over-expressed in various kinds of tumors …
to self-antigens. Heat shock protein 70 (HSP70) is over-expressed in various kinds of tumors …
Targeting of the non-mutated tumor antigen HER2/neu to mature dendritic cells induces an integrated immune response that protects against breast cancer in mice
B Wang, N Zaidi, LZ He, L Zhang, JMY Kuroiwa… - Breast cancer …, 2012 - Springer
Introduction Given their relative simplicity of manufacture and ability to be injected
repeatedly, vaccines in a protein format are attractive for breast and other cancers. However …
repeatedly, vaccines in a protein format are attractive for breast and other cancers. However …
Efficient induction of a Her2-specific anti-tumor response by dendritic cells pulsed with a Hsp70L1–Her2341–456 fusion protein
Q Fu, Y Wu, F Yan, N Wang, W Wang, X Cao… - Cellular & Molecular …, 2011 - nature.com
Heat shock proteins (HSPs) have been shown to interact with antigen-presenting cells
(APCs), especially dendritic cells (DCs). HSPs act as potent adjuvants, inducing a Th1 …
(APCs), especially dendritic cells (DCs). HSPs act as potent adjuvants, inducing a Th1 …