Antigenic cross‐reactivity between certain tumours has allowed the development of more
widely applicable, major histocompatibility complex‐disparate (allogeneic) whole‐cell …

In the current study, exposure of mammary tumor cells derived from mice transgenic for the
polyomavirus middle T oncogene to ionizing radiation resulted in the generation of a tumor …

Dendritic cells (DC) engineered in vitro by DNA encoding OVAhsp70 and IL-15 up-regulated
their expressions of CD80, CD86, CCR7 and IL-15Rα and promoted their productions of IL …

Tumor cells harbor a repertoire of unique, mutated antigens and shared self-antigens but
generally are incapable of provoking an effective immune response, likely because of …

Abstract Heat-shock protein (HSP)-based immunotherapy is established on its adjuvant
effects when applied via an extracellular approach to pulse and activate dendritic cells …

Vaccination with autologous tumor‐derived heat shock proteins (Hsp), such as Hsp70,
Hsp90 and gp96, has been demonstrated to elicit specific immune responses against the …

Purpose: Despite promising advances in breast cancer immunotherapy, augmenting T-cell
infiltration has remained a significant challenge. Although neither individual vaccines nor …

Each tumor harbors unique repertoire of mutated antigenic peptides that are immunogenic
and potentially can induce tumor-specific immune responses. Because heat shock proteins …

Geldanamycin (GA), a heat-shock protein (HSP) 90 inhibitor, induces degradation of HSP90
client proteins, which may promote the presentation of degradation peptides with major …

To improve the efficacy of tumor cell-based and dendritic cell (DC)-based cancer vaccines,
this study explored the potential of a new cancer vaccine strategy, that is, the use of CD40 …