Controlling intracranial pressure, nerve cell regeneration, and microenvironment regulation
are the key issues in reducing mortality and disability in acute brain injury. There is currently …

Spinal cord injury is a serious disease of the central nervous system involving irreversible
nerve injury and various organ system injuries. At present, no effective clinical treatment …

Hibernation is a unique physiological state that evolved to survive periods of food shortages.
It is characterized by profound decreases in metabolic rate, body temperature and …

Hypothermia is a well established cytoprotectant, with remarkable and consistent effects
demonstrated across multiple laboratories. At the clinical level, it has recently been shown to …

Stroke is a leading cause of disability and death, yet effective treatments for acute stroke has
been very limited. Thus far, tissue plasminogen activator has been the only FDA-approved …

Many mammalian species naturally undergo hibernation, a process that is associated with
drastic changes in metabolism and systemic physiology. Their ability to retain an …

Through the years, the clinical application of mild hypothermia has been carried out
worldwide and is built from the exploration and cognition of neuroprotection mechanisms by …

Besides local neuronal damage caused by the primary insult, central nervous system
injuries may secondarily cause a progressive cascade of related events including brain …

This study is to explore the application of target temperature management and therapeutic
hypothermia in the treatment of neuroprotection patients with severe traumatic brain injury …

Hibernation, a natural model of tolerance to cerebral ischemia, represents a state of
pronounced fluctuation in cerebral blood flow where no brain damage occurs. Numerous …