G-四链体及其配体在植物病毒中的功能研究

张宪鹏, 徐鸿宇, 张勇, 马建, 王杰, 石绪根 - 农药学学报, 2024 - nyxxb.cn
G-四链体是一种特殊的非标准核酸二级结构, 在多种生命活动过程中发挥重要的调控作用.
近年来研究发现, G-四链体结构在农业植物病毒基因组中广泛存在, 并参与病毒的复制等过程 …

Biological functions of G-quadruplexes and the ligands in plant viruses

Z Xianpeng, XU Hongyu, Z Yong, MA Jian… - Chinese Journal of …, 2024 - nyxxb.cn
Abstract G-quadruplexes (G4s) are non-canonical secondary structure of nucleic acids that
play vital roles in various biological processes. Recent studies have showed that G4s are …

Unlocking G-quadruplexes as antiviral targets

A Abiri, M Lavigne, M Rezaei, S Nikzad, P Zare… - Pharmacological …, 2021 - ASPET
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …

靶向G-四链体的抗番茄丛矮病毒卟啉类衍生物的筛选

谢从宝, 祝强强, 张涛, 宁丽红, 位灯国 - 农药学学报, 2023 - nyxxb.cn
植物病毒病给蔬菜生产带来很大影响, 目前蔬菜病毒防控主要采用非药剂措施,
广谱抗病毒剂效果有限, 需要基于新的药物靶点开发新的病毒抑制剂. G-四链体(G4s) …

[HTML][HTML] G quadruplex in plants: a ubiquitous regulatory element and its biological relevance

V Yadav, null Hemansi, N Kim, N Tuteja… - Frontiers in Plant …, 2017 - frontiersin.org
G quadruplexes (G4) are higher-order DNA and RNA secondary structures formed by G-rich
sequences that are built around tetrads of hydrogen-bonded guanine bases. Potential G4 …

[HTML][HTML] Plant G-quadruplex (G4) motifs in DNA and RNA; abundant, intriguing sequences of unknown function

BD Griffin, HW Bass - Plant Science, 2018 - Elsevier
DNA sequences capable of forming G-quadruplex (G4) structures can be predicted and
mapped in plant genomes using computerized pattern search programs. Non-telomeric G4 …

DNA 鸟嘌呤四联体研究进展

冯逸龙, 张文利 - 生物技术通报, 2020 - biotech.aiijournal.com
鸟嘌呤(G) 四联体(G-quadruplex, G4), 是指在DNA 或RNA 链中, 富含G 碱基的区域通过
Hoogsteen 氢键配对使G 环互联形成的一种四链二级结构. 人和动物的研究结果表明, G4 …

[HTML][HTML] Exploring the Relationship between G-Quadruplex Nucleic Acids and Plants: From Plant G-Quadruplex Function to Phytochemical G4 Ligands with …

AP Falanga, M Terracciano, G Oliviero, GN Roviello… - Pharmaceutics, 2022 - mdpi.com
G-quadruplex (G4) oligonucleotides are higher-order DNA and RNA secondary structures of
enormous relevance due to their implication in several biological processes and …

Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy

E Ruggiero, SN Richter - Annual reports in medicinal chemistry, 2020 - Elsevier
Viruses are the most abundant organisms on our planet, affecting all living beings: some of
them are responsible for massive epidemics that concern health, national economies and …

Identification and functional characterization of G-quadruplexes in plants

X Ma, Y Feng, Z Luo, W Zhang - Trends in Plant Science, 2022 - cell.com
DNA (G4-DNA) or RNA (G4-RNA) G-quadruplexes, which are formed within guanine-rich
nucleic acid context harboring putative G4-forming sequences (PQSs), are prevalent in …