可溶性p75 神经营养受体作为神经退行性疾病的可靠生物标志物: 证据是什么?

G Jourdi, S Fleury, I Boukhatem… - 中国神经再生研究(英文 …, 2024 - sjzsyj.com.cn
Neurodegenerative diseases are often misdiagnosed, especially when the diagnosis is
based solely on clinical symptoms. The p75 neurotrophic receptor (p75NTR) has been …

Soluble p75 neurotrophic receptor as a reliable biomarker in neurodegenerative diseases: what is the evidence?

G Jourdi, S Fleury, I Boukhatem… - Neural Regeneration …, 2023 - journals.lww.com
Neurodegenerative diseases are often misdiagnosed, especially when the diagnosis is
based solely on clinical symptoms. The p75 neurotrophic receptor (p75NTR) has been …

Differential levels of p75NTR ectodomain in CSF and blood in patients with Alzheimer's disease: a novel diagnostic marker

SS Jiao, XL Bu, YH Liu, QH Wang, CH Liu… - Translational …, 2015 - nature.com
Alzheimer's disease (AD) is the primary cause of dementia in the elderly. The ectodomain of
p75 neurotrophin receptor (p75NTR-ECD) has been suggested to play important roles in …

p75 神经营养因子受体在神经退行性疾病中的作用

秦晓颖, 刘刚, 廖红 - 中国药理学通报, 2022 - cqvip.com
近年来, 研究发现神经营养因子受体p75NTR 在包括阿尔茨海默症(Alzheimer's disease, AD),
帕金森病(Parkinson′ s disease, PD), 亨廷顿病(Huntington′ s disease, HD) …

Update on the role of p75NTR in neurological disorders: A novel therapeutic target

YH Shu, XM Lu, JX Wei, L Xiao, YT Wang - Biomedicine & …, 2015 - Elsevier
As a low-affinity neurotrophins receptor, p75 neurotrophin receptor (p75NTR) is a
transmembrane receptor involved in a diverse array of cellular responses, including …

Clinical Correlates Identify ProBDNF and Thrombo-Inflammatory Markers as Key Predictors of Circulating p75NTR Extracellular Domain Levels in Older Adults

S Fleury, ME Schnitzer… - Frontiers in Aging …, 2022 - frontiersin.org
The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal
survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been …

p75NTR: A Molecule with Multiple Functions in Amyloid-β Metabolism and Neurotoxicity

LL Shen, F Zeng, K Saadipour, JJ Lu, XF Zhou… - Handbook of …, 2023 - Springer
Alzheimer's disease (AD) is the most common form of dementia among the elderly. Amyloid-
β (Aβ) accumulation and the downstream pathological events, such as neurofibrillary …

A monoclonal antibody against the extracellular domain of p75 neurotrophin receptor

YH Li, Y Jiang, J Xiong, XF Zhou… - Monoclonal Antibodies …, 2013 - liebertpub.com
The aim of this study was to prepare and identify a monoclonal antibody against the
extracellular domain of p75 neurotrophin receptor (p75NTR-ECD), which will be used in …

Neurotrophin receptor p75 mRNA level in peripheral blood cells of patients with Alzheimer's disease

Y Xu, WW Li, J Wang, C Zhu, YY Shen, AY Shi… - Neurotoxicity …, 2019 - Springer
The neurotrophin receptor p75 (p75NTR) plays important roles in regulating amyloid-beta
(Aβ) metabolism in the brain. The expression of p75NTR is altered in the brain of patients …

P75 neurotrophin receptor as a therapeutic target for drug development to treat neurological diseases

LL Xiong, L Chen, IB Deng, XF Zhou… - European Journal of …, 2022 - Wiley Online Library
The interaction of neurotrophins with their receptors is involved in the pathogenesis and
progression of various neurological diseases, including Alzheimer's disease, Parkinson's …