[HTML][HTML] 胆固醇敏感器SCAP 功能失调通过上调P2X7 受体表达促进THP-1 源性巨噬细胞炎症小体活化
伍莎莎， 欧阳南， 何泉， 周超 - 2017 - aammt.tmmu.edu.cn
目的探讨胆固醇调节原件结合蛋白裂解激活蛋白(sterol regulatory element binding proteins
cleavage-activating protein, SCAP) 功能失调促进THP-1 源性巨噬细胞炎症小体活化及IL-1β …
cleavage-activating protein, SCAP) 功能失调促进THP-1 源性巨噬细胞炎症小体活化及IL-1β …
胆固醇敏感器SCAP 功能失调对THP-1 源性巨噬细胞炎症因子表达的影响
欧阳南， 杜晓刚， 陈利群， 周超 - 第三军医大学学报, 2016 - cqvip.com
目的观察胆固醇调节元件结合蛋白裂解激活蛋白(sterol regulatory element binding proteins
cleavage-activating protein, SCAP) 功能失调对THP-1 源性巨噬细胞脂质代谢及IL-1β, MCP-1 …
cleavage-activating protein, SCAP) 功能失调对THP-1 源性巨噬细胞脂质代谢及IL-1β, MCP-1 …
Dysfunction of cholesterol sensor SCAP promotes inflammation activation in THP-1 macrophages
N Ouyang, H Gan, Q He, H Lei, SY Wang, Q Liu… - Experimental Cell …, 2018 - Elsevier
Crosstalk occurs between dyslipidemia and chronic inflammation, which are both
precipitants of atherosclerosis. Sterol regulatory element binding proteins cleavage …
precipitants of atherosclerosis. Sterol regulatory element binding proteins cleavage …
[HTML][HTML] 血管平滑肌SCAP 过表达抑制自噬促进脂质积聚的机制研究
饶雨涵， 李丹阳， 侯晓俐， 姚盈程， 苏玉， 陈压西… - 2022 - aammt.tmmu.edu.cn
目的探讨固醇调节元件结合蛋白裂解活化蛋白(sterol regulatory element binding proteins
cleavage activating protein, SCAP) 对血管平滑肌细胞(vascular smooth muscle cells …
cleavage activating protein, SCAP) 对血管平滑肌细胞(vascular smooth muscle cells …
[HTML][HTML] Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation
C Zhou, H Lei, Y Chen, Q Liu, LC Li, JF Moorhead… - PLoS …, 2013 - journals.plos.org
Inflammatory stress promotes foam cell formation by disrupting LDL receptor feedback
regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) …
regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) …
炎症诱导SCAP 功能失调促进ApoE^(-/-) 小鼠动脉粥样硬化的分子机制
周超， 季新忠， 刘巧， 伍莎莎， 欧阳南 - 第三军医大学学报, 2016 - cqvip.com
目的探讨炎症诱导胆固醇调节元件结合蛋白裂解激活蛋白(sterol regulatory element binding
proteins cleavage-activating protein, SCAP) 功能失调促进ApoE~(-/-) 小鼠动脉粥样硬化形成 …
proteins cleavage-activating protein, SCAP) 功能失调促进ApoE~(-/-) 小鼠动脉粥样硬化形成 …
炎症通过SCAP-SREBP2-LDLr 途径促进四氯化碳诱导的小鼠脂肪变肝细胞胆固醇内流
田琳， 刘宏， 谢友红 - 第三军医大学学报, 2014 - cqvip.com
目的探讨炎症促进CCl4 所致的单纯性脂肪变肝细胞进一步脂质集聚形成脂肪肝的分子机制.
方法将12 只6~ 8 周龄的C57BL/6J 雄性小鼠采用随机数字表法分为对照组(n= 6) 和炎症组(n …
方法将12 只6~ 8 周龄的C57BL/6J 雄性小鼠采用随机数字表法分为对照组(n= 6) 和炎症组(n …
[HTML][HTML] Macrophage SCAP contributes to metaflammation and lean NAFLD by activating STING–NF-κB signaling pathway
X Huang, Y Yao, X Hou, L Wei, Y Rao, Y Su… - Cellular and Molecular …, 2022 - Elsevier
Background & Aims Sterol regulatory element binding protein cleavage-activating protein
(SCAP) is a cholesterol sensor that confers a broad range of functional effects in metabolic …
(SCAP) is a cholesterol sensor that confers a broad range of functional effects in metabolic …
Experiment of THP-1 macrophage foam-cell formation through mTOR signal pathway activation induced by inflammatory stress
S Zhao, Q YE, T LI, Z Fan - Chinese Pharmacological Bulletin, 2016 - pesquisa.bvsalud.org
Aim To investigate if LPS increases the sterol regulatory element binding proteins (SREBPs)
cleavage-activating protein (SCAP)-SREBP2 expres-sion by activation of mTOR signal …
cleavage-activating protein (SCAP)-SREBP2 expres-sion by activation of mTOR signal …
[HTML][HTML] 炎症应激通过激活mTOR 通路诱导THP-1 巨噬细胞泡沫化的实验研究
赵爽， 叶强， 李涛， 范忠才 - 2016 - html.rhhz.net
目的研究脂多糖(LPS) 诱导的炎症应激是否通过激活mTOR 通路, 增加SCAP/SREBP2 表达,
干扰SCAP/SREBP2 负反馈调控, 增加THP-1 巨噬细胞对非修饰低密度脂蛋白胆固醇(LDL) …
干扰SCAP/SREBP2 负反馈调控, 增加THP-1 巨噬细胞对非修饰低密度脂蛋白胆固醇(LDL) …