The surgical sapecimen, cell line and xenografted tumor exhibited the characteristics of
glioma under electron microscopy. Immunohistochemical staining for GFAP, vimentin and …

Background and purpose Glioblastoma is the most common malignant CNS tumor, its
surgical removal is hindered by the tumors invasive nature, while current anti-tumor …

Recent advances in molecular biology have led to new insights in the development, growth
and infiltrative behaviors of primary brain tumors (Demuth and Berens, 2004; Huse and …

Purpose. The primary cause of local recurrence and therapeutic failure in the treatment of
malignant gliomas is the invasion of tumor cells into the surrounding normal brain. While it is …

We read with interest the review by Lun et al. about the natural history of extra-cranial
metastasis from glioblastoma multiform (GBM). The reports included were selected on the …

A number of important questions remain for future investigation. For example, Ratliff et al.
used immunocompromised mice, and one wonders to what extent the Go and Grow …

Tumors of glial origin consist of a core mass and a penumbra of invasive, single cells,
decreasing in numbers towards the periphery and still detectable several centimeters away …

OBJECTIVE: Invasive behaviors of malignant gliomas are fundamental traits and major
reasons for treatment failure. Delineation of invasive growth is important in establishing …

Background: Pattern of recurrence of glioblastoma (GBM) seems to have undergone some
shifts from distant metastasis as a rarity to a higher proportion, including disease …

4. Nakada M, Kita D, Futami K, et al: Roles of membrane type 1 matrix metalloproteinase
and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human …