Pain is one of the most complex and unpleasant sensory and emotional human
experiences. Pain relief continues to be a major medical challenge. The application of …

Materials and methods: After approval by our institutional animal investigation committee, 31
male, adult Wistar-albino rats weighing 250-300 g underwent sciatic nerve ligation under …

Background Magnesium is an antagonist of (N-methyl D-Aspartate) NMDA receptor and its
related canals, and may affect perceived pain. Objectives The aim of this study was to …

Until recently, the function of magnesium in biological processes was largely ignored to the
point where it was described as the 'forgotten ion'. However, in the last few years there has …

Background The use of low concentrations of volatile anaesthetics with avoidance of opioids
may induce intraoperative awareness and adverse haemodynamic responses during …

Opioids are increasingly used in alleviating pain, including cancer-related pain and
postoperative pain. Unfortunately, the development of tolerance, the resistance of …

Magnesium is a naturally occurring element and essential to human physiology and
homeostasis at the cellular level. In the past few decades it has been suggested that it has …

Previous studies have suggested that magnesium may be a useful adjuvant to postoperative
analgesia. We investigated efficacy of intravenous infusion of magnesium sulfate during …