甲磺酸萘莫司他可减轻神经缺血后的病理生理性损害

GZ Ghali, MGZ Ghali - 中国神经再生研究(英文版), 2020 - sjzsyj.com.cn
Nafamostat mesylate, an apparent soi-disant panacea of sorts, is widely used to
anticoagulate patients undergoing hemodialysis or cardiopulmonary bypass, mitigate the …

Nafamostat mesylate attenuates the pathophysiologic sequelae of neurovascular ischemia

GZ Ghali, MGZ Ghali - Neural Regeneration Research, 2020 - journals.lww.com
Nafamostat mesylate, an apparent soi-disant panacea of sorts, is widely used to
anticoagulate patients undergoing hemodialysis or cardiopulmonary bypass, mitigate the …

Nafamostat mesilate attenuates transient focal ischemia/reperfusion-induced brain injury via the inhibition of endoplasmic reticulum stress

SK Kwon, M Ahn, HJ Song, SK Kang, SB Jung… - Brain Research, 2015 - Elsevier
Nafamostat mesilate (NM), a serine protease inhibitor, has a broad range of clinical
applications that include use as an anticoagulant during hemodialysis in cerebral …

Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibition

T Chen, J Wang, C Li, W Zhang, L Zhang, L An… - Scientific reports, 2014 - nature.com
Evidence suggests that thrombin, a blood coagulation serine protease, mediates neuronal
injury in experimental cerebral ischemia. Here, we test the hypothesis that nafamostat …

Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats

C Zhao, T Zhou, X Zhao, Y Pang, W Li, B Fan… - Journal of …, 2022 - Springer
Background Nafamostat mesylate (nafamostat, NM) is an FDA-approved serine protease
inhibitor that exerts anti-neuroinflammation and neuroprotective effects following rat spinal …

Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats

C Li, J Wang, Y Fang, Y Liu, T Chen, H Sun… - Brain, behavior, and …, 2016 - Elsevier
Inflammation plays an important role in stroke pathology, making it a promising target for
stroke intervention. Nafamostat mesilate (NM), a wide-spectrum serine protease inhibitor, is …

[HTML][HTML] Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice

H Matsubara, T Imai, S Tsuji, N Oka, Y Egashira… - Journal of …, 2022 - Elsevier
This study aimed to evaluate the effects of nafamostat, a serin protease inhibitor, in the
management of subarachnoid hemorrhage (SAH). SAH was induced by endovascular …

DL-3-n-butylphthalide prevents neuronal cell death after focal cerebral ischemia in mice via the JNK pathway

J Li, Y Li, M Ogle, X Zhou, M Song, SP Yu, L Wei - Brain research, 2010 - Elsevier
dl-3-n-Butylphthalide (NBP) has shown cytoprotective effects in animal models of stroke and
has passed clinical trials as a therapeutic drug for stroke in China. Hence, as a potential …

Clematichinenoside facilitates recovery of neurological and motor function in rats after cerebral ischemic injury through inhibiting notch/NF-κB pathway

D Xu, N Xia, K Hou, F Li, S Chen, Y Hu, W Fang… - Journal of Stroke and …, 2019 - Elsevier
Purpose: The present study was to observe the therapeutic efficiency of Clematichinenoside
(AR) on cerebral ischemic injury in rats, especially on neurological and motor function …

Neutroprotective efficacy of sodium tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia

Q Cai, H Wang, S Hua, J Tan, T Zhou, C Li - Chinese journal of integrative …, 2012 - Springer
Objective To investigate the protective effects of sodium tanshinone B (STB) on brain
damage following focal ischemia-reperfusion (I/R) injury through interfering with N-methyl-D …