Interferon gamma (IFN-γ) is an immunomodulatory and anti-microbial cytokine, which has a
variety of proatherogenic effects. It has been reported that IFN-γ can down-regulate ABCA1 …

S100A8/9 and S100A12 are emerging biomarkers for disease activity of autoimmune and
cardiovascular diseases. We demonstrated previously that S100A12 accelerates …

Long-term cytokine-mediated inflammation is a risk factor for obesity and type 2 diabetes
mellitus (T2DM). Our previous studies reveal significant associations between promoter …

Objective The aim of this study was to determine whether ATP-binding cassette transporter
A1 (ABCA1) was up-regulated by growth differentiation factor-15 (GDF-15) via the …

In atherogenesis, macrophage foam cell formation is modulated by pathways involving both
the uptake and efflux of cholesterol. We recently showed that interleukin-10 (IL-10) …

Abstract Macrophage-activating lipopeptide-2 (MALP-2) has been shown to promote the
development of atherosclerosis. ATP-binding cassette transporter A1 (ABCA1), a …

Rationale Excessive cholesterol accumulation in macrophages is a major factor of foam cell
formation and development of atherosclerosis. Previous studies suggested that miR-486 …

Atherosclerosis (AS) is characterized by dyslipidemia and chronic inflammation. In the high-
fat environment, the lipid metabolism of dendritic cells (DCs) is abnormal, which leads to …

Toll-like receptors (TLR) activation is thought to modulate the macrophage cholesterol efflux
and contribute to the atherosclerosis progression; however, the precise pathophysiological …

Objective—Recent studies have shown the role of miRNAs in macrophage reverse
cholesterol transport and atherogenesis. We hypothesized that coenzyme Q10 (CoQ10) may …