A double‐blind, placebo‐controlled trial of sibutramine for clozapine‐associated weight gain

DC Henderson, X Fan, PM Copeland… - Acta Psychiatrica …, 2007 - Wiley Online Library
Objective: This study sought to examine the effectiveness of sibutramine, a weight loss
agent, on clozapine‐associated weight gain. Method: This was a 12‐week double‐blind …

Sibutramine in the treatment of antipsychotic-induced weight gain: a pilot study in patients with schizophrenia

F Biedermann, WW Fleischhacker… - International clinical …, 2014 - journals.lww.com
Weight gain represents a frequent side effect of antipsychotic drug treatment. The current
trial investigated the effect of add-on treatment with sibutramine in schizophrenia outpatients …

A double-blind, placebo-controlled trial of sibutramine for olanzapine-associated weight gain

DC Henderson, PM Copeland… - American Journal of …, 2005 - Am Psychiatric Assoc
OBJECTIVE: Weight gain is commonly observed with olanzapine treatment and can
increase the risk for obesity, cardiovascular disease, hypertension, and diabetes mellitus …

Clozapine-induced weight gain: prevalence and clinical relevance.

R Leadbetter, M Shutty, D Pavalonis… - The American journal …, 1992 - europepmc.org
Objective The aim of this study was to determine the prevalence and clinical relevance of
weight gain during clozapine treatment. Previous reports indicated clinically significant …

Phenylpropanolamine appears not to promote weight loss in patients with schizophrenia who have gained weight during clozapine treatment

JC White, VM Steele, GE Jaskiw - J Clin Psychiatry, 2002 - psychiatrist.com
Background: Weight gain is a common side effect of clozapine treatment and may expose
patients to obesity-associated health risks. We proposed that concomitant treatment with an …

Association of initial antipsychotic response to clozapine and long-term weight gain

YM Bai, CC Lin, JY Chen, CY Lin… - American Journal of …, 2006 - Am Psychiatric Assoc
Objective: The aim of this study was to test whether the initial antipsychotic response to
clozapine is related to subsequent weight change. Method: This study was an 8-year …

Differential effect of clozapine on weight: a controlled study.

JR Bustillo, RW Buchanan, D Irish… - The American journal of …, 1996 - europepmc.org
Objective This study examined whether clozapine induces more weight gain than
haloperidol and whether weight gain is related to clinical improvement. Method The weight …

Clozapine and weight gain.

DS Umbricht, S Pollack, JM Kane - The Journal of clinical psychiatry, 1994 - europepmc.org
Background To investigate the association of clozapine treatment and weight gain, we
studied short-and long-term weight gain, correlation of weight gain with treatment response …

Clozapine-induced weight gain predicts improvement in psychopathology

HY Meltzer, E Perry, K Jayathilake - Schizophrenia research, 2003 - Elsevier
Background: Some, but not all, previous studies have indicated that weight gain is
associated with greater improvement in psychopathology during clozapine treatment …

[HTML][HTML] Metformin for treatment of clozapine-induced weight gain in adult patients with schizophrenia: a meta-analysis

LIU Zhengrong, W Zheng, GAO Shuai… - Shanghai Archives of …, 2015 - ncbi.nlm.nih.gov
Background Long-term use of clozapine for individuals with schizophrenia carries a high risk
for developing metabolic abnormalities, especially clozapine-induced weight gain. Previous …