Research advances in TET enzyme and its intermediate product 5hmC

J Wu, X Fang, X Xia, M Zhang - Zhong nan da xue xue bao. Yi xue …, 2019 - europepmc.org
DNA methylation is a significant epigenetic modification mode, which plays an important role
in embryo reprogramming, stem cell differentiation and tumor occurrence. The ten-eleven …

Roles of ten eleven translocation proteins family and 5-hydroxymethylcytosine in epigenetic regulation of stem cells and regenerative medicine

JF Zhao, D Li, Y An - Beijing da xue xue bao. Yi xue ban= Journal of …, 2021 - europepmc.org
The methylation of cytosine is one of the most fundamental epigenetic modifications in
mammalian genomes, and is involved in multiple crucial processes including gene …

Structure and function of TET enzymes

X Yin, L Hu, Y Xu - DNA Methyltransferases-Role and Function, 2022 - Springer
Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC).
TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine …

Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development.

ZW Jia, SX Gao, YC Zhang, XH Zhang - Yi chuan= Hereditas, 2015 - europepmc.org
TET (ten-eleven translocation) protein family includes three members TET1, TET2 and TET3,
which belong to alpha-ketoglutaric acid (α-KG)-and Fe (2+)-dependent dioxygenase …

[HTML][HTML] TET 蛋白家族与5-羟甲基胞嘧啶在干细胞及再生医学表观遗传调控中的作用

赵健芳, 李东, 安阳 - Journal of Peking University (Health Sciences …, 2021 - ncbi.nlm.nih.gov
The methylation of cytosine is one of the most fundamental epigenetic modifications in
mammalian genomes, and is involved in multiple crucial processes including gene …

Structure and function of TET enzymes

X Yin, Y Xu - DNA methyltransferases-role and function, 2016 - Springer
Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC).
TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine …

[PDF][PDF] TET enzymes and 5hmC epigenetic mark: new key players in carcinogenesis and progression in gynecological cancers.

AE Zacapala-Gómez… - European Review for …, 2024 - europeanreview.org
DNA methylation is an epigenetic mechanism involving the transfer of a methyl group onto
the C5 position of the cytosine to form 5-methylcytosine (5mC). In general, DNA methylation …

Loss of 5‐hydroxymethylcytosine is accompanied with malignant cellular transformation

Y Kudo, K Tateishi, K Yamamoto, S Yamamoto… - Cancer …, 2012 - Wiley Online Library
Dysregulated DNA methylation followed by abnormal gene expression is an epigenetic
hallmark in cancer. DNA methylation is catalyzed by DNA methyltransferases, and the …

Acetylation regulates TET2 stability and enzymatic activity

Y Zhang, Y Cai, W Xie, H Easwaran, SB Baylin - Cancer Research, 2015 - AACR
DNA methylation, one of the key epigenetic modifications in the mammalian genome, plays
fundamental roles in development and disease. Although DNA methylation and DNA …

TETology: epigenetic mastermind in action

A Seethy, K Pethusamy, I Chattopadhyay… - Applied Biochemistry …, 2021 - Springer
Cytosine methylation is a well-explored epigenetic modification mediated by DNA
methyltransferases (DNMTs) which are considered “methylation writers”; cytosine …