以質譜為基礎的醣質體及醣蛋白質體大多著重在鑑定醣鏈末端乙酰基乳糖胺上的唾液酸及岩藻
醣化, 對於N 型醣鏈上是否為直鏈或是帶有支鏈的多乳糖胺聚醣則較少著墨 …

Most mass spectrometry (MS)-based glycomic and glycoproteomic analyses focus on
identifying changes in terminal glyco-epitopes represented by sialylation and fucosylation at …

Sialylation is important in producing therapeutic proteins such as antibody, cytokine and
fusion protein. Thus, enhancement of sialylation is usually performed in CHO cell cultures …

聚醣是由數個單醣藉由糖苷鍵連結而成, 由於醣蛋白中的聚醣結構具有高度複雜性,
因此了解聚醣中單糖的組成與鍵結就成為重要的工作. 在本實驗中開發一個方法 …

Sulfate modification (sulfation) on terminal glyco-epitopes (glycotopes) has been
demonstrated as a critical element that mediates many important biological processes …

Sialic acid, a monosaccharide containing nine carbon atoms, is widely distributed in
eukaryotic cells. The bound sialic acids are mainly present at the glycan ends of …

九碳糖唾液酸是位於生物體醣質末端的修飾分子, 它是細胞與細胞間的溝通橋樑,
也是傳達訊息的細胞表面辨識分子. 位於細胞表面的醣分子常常可以反應細胞的生理狀態 …

位於非還原端醣抗原決定位(glyco-epitopes) 上的硫酸化(sulfation) 被指出調控多種重要的生物
機制, 其中包含人類淋巴球周邊淋巴結歸巢行為(homing). 由於O 與N 型硫酸化醣鏈在細胞內 …

We found that human peripheral B and T cells differed in the surface expression of α2–6
sialylated type 2 chain glycans. In contrast to B cells, T cells expressed only sialoglycans …

半乳糖凝集素家族(galectins) 是一群可以辨識β-半乳糖苷(β-galactosides) 單元的蛋白家族.
它們在調控生物的生理活性上扮演了重要角色. 像是半乳糖凝集素-8 (galectin-8, Gal-8) …