Adeno-associated virus vectors in clinical trials
BJ Carter - Human gene therapy, 2005 - liebertpub.com
ADENO-ASSOCIATED VIRUS (AAV) VECTORS were first devel-oped 20 years ago (Carter,
2004) and an AAV vector was first administered to a human subject in November 1995 …
2004) and an AAV vector was first administered to a human subject in November 1995 …
Adeno-associated virus types 5 and 6 use distinct receptors for cell entry
MP Seiler, AD Miller, J Zabner, CL Halbert - Human gene therapy, 2006 - liebertpub.com
The transduction efficiency of adeno-associated virus (AAV) vectors in various somatic
tissues is determined primarily by the viral capsid proteins. In contrast to vectors made with …
tissues is determined primarily by the viral capsid proteins. In contrast to vectors made with …
Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors
CL Halbert, JM Allen, AD Miller - Journal of virology, 2001 - Am Soc Microbiol
Although vectors derived from adeno-associated virus type 2 (AAV2) promote gene transfer
and expression in many somatic tissues, studies with animal models and cultured cells show …
and expression in many somatic tissues, studies with animal models and cultured cells show …
Production methods for gene transfer vectors based on adeno-associated virus serotypes
D Grimm - Methods, 2002 - Elsevier
Vectors derived from adeno-associated virus serotype 2 (AAV-2) represent a most promising
tool for human gene transfer because these vectors are neither pathogenic nor toxic to the …
tool for human gene transfer because these vectors are neither pathogenic nor toxic to the …
Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes
CL Halbert, EA Rutledge, JM Allen, DW Russell… - Journal of …, 2000 - Am Soc Microbiol
Vectors derived from adeno-associated virus type 2 (AAV2) promote gene transfer and
expression in the lung; however, we have found that while gene expression can persist for at …
expression in the lung; however, we have found that while gene expression can persist for at …
Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro
MP Limberis, LH Vandenberghe, L Zhang, RJ Pickles… - Molecular Therapy, 2009 - cell.com
We have characterized the ability of adeno-associated virus (AAV) serotypes 1–9 in addition
to nineteen novel vectors isolated from various tissues, to transduce mouse and human …
to nineteen novel vectors isolated from various tissues, to transduce mouse and human …
Long-term persistence of gene expression from adeno-associated virus serotype 5 in the mouse airways
SG Sumner-Jones, LA Davies, A Varathalingam… - Gene therapy, 2006 - nature.com
Recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) have been used
to deliver transgenes to the airways in a variety of pre-clinical and clinical studies. Gene …
to deliver transgenes to the airways in a variety of pre-clinical and clinical studies. Gene …
[PDF][PDF] Incorporation of Adeno-Associated Virus in
CP Coprecipitate - J. Virol, 2000 - Citeseer
Adeno-associated virus (AAV) is inefficient at infecting differentiated airway epithelia
because of a lack of receptors at the apical surface. We hypothesized that incorporation of …
because of a lack of receptors at the apical surface. We hypothesized that incorporation of …
Identification of the galactose binding domain of the adeno-associated virus serotype 9 capsid
CL Bell, BL Gurda, K Van Vliet… - Journal of …, 2012 - Am Soc Microbiol
Adeno-associated virus serotype 9 (AAV9) vectors show promise for gene therapy of a
variety of diseases due to their ability to transduce multiple tissues, including heart, skeletal …
variety of diseases due to their ability to transduce multiple tissues, including heart, skeletal …