摘要在胰岛β 细胞中, 线粒体内的三磷酸腺苷(Adenosine triphosphate, ATP)
的合成及分泌对调控胰岛素分泌起重要作用. ATP 合成速率降低是线粒体功能障碍的主要表现 …

Under physiological conditions, insulin secretion from pancreatic β-cells is tightly regulated
by different factors, including nutrients, nervous system, and other hormones. Pancreatic β …

It is well known that adenosine triphosphate plays an important intracellular role in the
insulin-secreting pancreatic B cell. For many years ATP was only considered as being an …

Non-insulin-dependent diabetes meilitus (NIDDM) is a heterogeneous disease resulting
primarily from a variety of pancreatic [beta]-cell disorders and insulin resistance. Whereas …

Extracellular nucleotides modulate several cell functions via specific receptors, P2X and
P2Y. We explored the differential role of these receptors in the control of insulin secretion …

ATP has been previously identified as an autocrine signaling factor that is co‐released with
insulin to modulate and propagate β‐cell activity within islets of Langerhans. Here, we show …

Extracellular ATP has been proposed as a paracrine signal in rodent islets, but it is unclear
what role ATP plays in human islets. We now show the presence of an ATP signaling …

Purpose The role of ATP, which is secreted by pancreatic β-cells, is still a matter of debate. It
has been postulated that extracellular ATP acts as a positive auto-or paracrine signal in β …

The mechanism by which extracellular ATP stimulates insulin secretion was investigated in
RINm5F cells. ATP depolarized the cells as demonstrated both by using the patch-clamp …

Three different methods, membrane capacitance (Cm) measurement, amperometry and FM
dye labeling were used to investigate the role of extracellular ATP in insulin secretion from …