DNA 损伤发生时, 细胞会激活一系列复杂的信号网络来调控细胞周期检查, 完成DNA
损伤修复或当损伤超过修复能力时诱导凋亡, 这一信号网络被称为DNA 损伤反应(DNA damage …

In response to DNA damage, a complex signaling network called DNA damage response
(DDR) would be activated in cells, to arrest the cell cycle and initiate DNA repair. Previous …

Maintenance of genome integrity is essential for the proper function of all cells and
organisms. In response to both endogenous and exogenous DNA damaging agents …

Upon DNA damage, cells trigger an early DNA-damage response (DDR) involving DNA
repair and cell cycle checkpoints, and late responses involving gene expression regulation …

In response to DNA damage, cells activate a complex, kinase-based signaling network to
arrest the cell cycle and allow time for DNA repair, or, if the extend of damage is beyond …

Genomic stability is critical for cell survival and its effective repair when damaged is a vital
process for preserving genetic information. Failure to correctly repair the genome can lead to …

The DNA damage response (DDR) is a signal transduction pathway that decides the cell's
fate either to repair DNA damage or to undergo apoptosis if there is too much damage. Post …

The mechanisms by which RNA acts in the DNA damage response (DDR), specifically in the
repair of DNA double-strand breaks (DSBs), are emerging as multifaceted and complex …

Non-coding RNAs play a crucial role in maintaining genomic stability which is essential for
cell survival and preventing tumorigenesis. Through an extensive crosstalk between non …

Many carcinogenic agents such as ultra-violet light from the sun and various natural and
man-made chemicals act by damaging the DNA. To deal with these potentially detrimental …