Dysfunction of cholesterol sensor SCAP promotes inflammation activation in THP-1 macrophages
N Ouyang, H Gan, Q He, H Lei, SY Wang, Q Liu… - Experimental Cell …, 2018 - Elsevier
Crosstalk occurs between dyslipidemia and chronic inflammation, which are both
precipitants of atherosclerosis. Sterol regulatory element binding proteins cleavage …
precipitants of atherosclerosis. Sterol regulatory element binding proteins cleavage …
[HTML][HTML] Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation
C Zhou, H Lei, Y Chen, Q Liu, LC Li, JF Moorhead… - PLoS …, 2013 - journals.plos.org
Inflammatory stress promotes foam cell formation by disrupting LDL receptor feedback
regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) …
regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) …
[HTML][HTML] Sterol-resistant SCAP overexpression in vascular smooth muscle cells accelerates atherosclerosis by increasing local vascular inflammation through …
D Li, M Liu, Z Li, G Zheng, A Chen, L Zhao… - Aging and …, 2021 - ncbi.nlm.nih.gov
Atherosclerosis is a serious age-related pathology, and one of its hallmarks is the presence
of chronic inflammation. Sterol regulatory element-binding protein (SREBP) cleavage …
of chronic inflammation. Sterol regulatory element-binding protein (SREBP) cleavage …
[HTML][HTML] Macrophage SCAP contributes to metaflammation and lean NAFLD by activating STING–NF-κB signaling pathway
X Huang, Y Yao, X Hou, L Wei, Y Rao, Y Su… - Cellular and Molecular …, 2022 - Elsevier
Background & Aims Sterol regulatory element binding protein cleavage-activating protein
(SCAP) is a cholesterol sensor that confers a broad range of functional effects in metabolic …
(SCAP) is a cholesterol sensor that confers a broad range of functional effects in metabolic …
[HTML][HTML] The cellular function of SCAP in metabolic signaling
SH Lee, JH Lee, SS Im - Experimental & molecular medicine, 2020 - nature.com
Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a
key regulator of SREBP maturation. SCAP induces translocation of SREBP from the …
key regulator of SREBP maturation. SCAP induces translocation of SREBP from the …
[HTML][HTML] SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization
JH Lee, SH Lee, EH Lee, JY Cho, DK Song… - Journal of Advanced …, 2023 - Elsevier
Introduction Sterol regulatory element binding protein (SREBP) cleavage-associating
protein (SCAP) is a sterol-regulated escort protein that translocates SREBPs from the …
protein (SCAP) is a sterol-regulated escort protein that translocates SREBPs from the …
Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines
Y Chen, X Ruan, A Huang, LI Qiu… - Chinese medical …, 2007 - journals.lww.com
Background Low-density lipoprotein (LDL) receptor is normally regulated via a feedback
system that is dependent on intracellular cholesterol levels. We have demonstrated that …
system that is dependent on intracellular cholesterol levels. We have demonstrated that …
SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE (-/-) mice
D Li, A Chen, T Lan, Y Zou, L Zhao, P Yang… - FASEB …, 2019 - discovery.ucl.ac.uk
Sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) is a
cholesterol sensor that plays a critical role in regulating intracellular cholesterol levels, but …
cholesterol sensor that plays a critical role in regulating intracellular cholesterol levels, but …
Inflammatory stress increases unmodified LDL uptake via LDL receptor: an alternative pathway for macrophage foam-cell formation
Q Ye, Y Chen, H Lei, Q Liu, JF Moorhead… - Inflammation …, 2009 - Springer
Objective To investigate if inflammatory stress increases intracellular accumulation of
unmodified low-density lipoprotein (LDL) in human monocyte cell line (THP-1) macrophages …
unmodified low-density lipoprotein (LDL) in human monocyte cell line (THP-1) macrophages …
Retrospective on cholesterol homeostasis: the central role of scap
MS Brown, A Radhakrishnan… - Annual review of …, 2018 - annualreviews.org
Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …