Abstract NF-E2-related factor 2 (Nrf2) has been shown to be protective in atherosclerosis.
The loss of Nrf2 in macrophages enhances foam cell formation and promotes early …

Sterol regulatory element binding proteins (SREBPs) function as transcription factors that
activate specific genes involved in cholesterol synthesis, endocytosis of low density …

To provide experimental evidence for the effect of inflammation on cholesterol accumulation
in macrophages, we investigated the expression of low-density lipoprotein receptor (LDL-R) …

Nonresolving inflammatory response from macrophages is a major characteristic of
atherosclerosis. Macrophage ABCA1 has been previously shown to suppress the secretion …

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance,
obesity, and dyslipidemia. NAFLD encompasses a wide range of states from the simple …

Macrophage polarization in response to environmental cues has emerged as an important
event in the development of atherosclerosis. Compelling evidences suggest that P21 …

Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that
control fatty acid and cholesterol metabolism. As the major SREBP isoform in macrophages …

Cholesterol metabolism has been linked to immune functions, but the mechanisms by which
cholesterol biosynthetic signaling orchestrates inflammasome activation remain unclear …

In liver, the synthesis of cholesterol and fatty acids increases in response to cholesterol
deprivation and insulin elevation, respectively. This regulatory mechanism underlies the …

P-selectin and dendritic cells (DCs) are associated with atherosclerosis. However, their
interactions in this setting are undefined. Herein, we investigated the role of P-selectin and …