轉基因斑馬魚過量表現第二型類胰島素生長因子訊息核醣核酸第二型結合蛋白導致脂肪肝形成
林明轅 - 2007 - airitilibrary.com
IMP2 最早是在肝癌病人上的自體抗原發現, 而IMP2 在肝癌發生過程中, 從慢性肝病像是脂肪肝,
肝硬化到肝癌發生中間的機制, 都尚未清楚. 到目前, 並沒有任何IMP2 的轉基因動物 …
肝硬化到肝癌發生中間的機制, 都尚未清楚. 到目前, 並沒有任何IMP2 的轉基因動物 …
IMP3 與NuSAP 基因在肝細胞癌的表現及其臨床病理和功能研究
鄭永銘 - 2009 - tdr.lib.ntu.edu.tw
為了闡明肝細胞癌的分子病理機制, 我們分析了網路上的微陣列資料庫, 找出兩個前人較少研究
的基因似胰島素生長因子mRNA 結合蛋白3 (IMP3) 和NuSAP 為肝細胞癌過度表現的基因 …
的基因似胰島素生長因子mRNA 結合蛋白3 (IMP3) 和NuSAP 為肝細胞癌過度表現的基因 …
[HTML][HTML] Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation
L Regué, L Minichiello, J Avruch, N Dai - Journal of Biological Chemistry, 2019 - ASBMB
Insulin-like growth factor 2 mRNA-binding proteins 1–3 (IGF2BP1–3, also known as IMP1–3)
contribute to the regulation of RNAs in a transcriptome-specific context. Global deletion of …
contribute to the regulation of RNAs in a transcriptome-specific context. Global deletion of …
[PDF][PDF] The authors are grateful to Nobuyuki Torisawa (Fujifilm, To-kyo, Japan) for his technical assistance.
Y Saito, T Uraoka, T Matsuda - Gastroenterol Hepatol, 2013 - mhlw-grants.niph.go.jp
In East Asian countries, esophageal squamous cell carcinoma (ESCC) is the major
histological form of esophageal cancer. The disease is also one of the most lethal digestive …
histological form of esophageal cancer. The disease is also one of the most lethal digestive …
[HTML][HTML] IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis
B Czepukojc, A Abuhaliema, A Barghash… - Frontiers in …, 2019 - frontiersin.org
The insulin-like growth factor 2 (IGF2) mRNA binding proteins (IMPs/IGF2BPs) IMP1 and 3
are regarded as oncofetal proteins, whereas the hepatic IMP2 expression in adults is …
are regarded as oncofetal proteins, whereas the hepatic IMP2 expression in adults is …
[HTML][HTML] IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype
SM Kessler, S Laggai, A Barghash… - Cell death & …, 2015 - nature.com
Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related
deaths and commonly develops in inflammatory environments. The IGF2 mRNA-binding …
deaths and commonly develops in inflammatory environments. The IGF2 mRNA-binding …
Insulin activates LC-PUFA biosynthesis of hepatocytes by regulating the PI3K/Akt/mTOR/Srebp1 pathway in teleost Siganus canaliculatus
L Liu, C Chen, Y Dong, Y Cheng, C You… - … and Physiology Part B …, 2022 - Elsevier
Insulin is well known an important metabolic regulator in glucose and lipid metabolism. It
has been proved to activate long-chain (≥ C 20) polyunsaturated fatty acids (LC-PUFA) …
has been proved to activate long-chain (≥ C 20) polyunsaturated fatty acids (LC-PUFA) …
P62/IMP2 promotes metastasis in hepatocellular carcinoma (HCC) by regulating EMT in different signaling pathway
Insulin-like growth factor 2 mRNA binding proteins (IMPs) Family contains three members:
IMP1, IMP2 and IMP3. IMPs are oncofetal proteins, expressed during embryogenesis and …
IMP1, IMP2 and IMP3. IMPs are oncofetal proteins, expressed during embryogenesis and …
Insulin and insulin-like growth factor I signaling pathways in rainbow trout (Oncorhynchus mykiss) during adipogenesis and their implication in glucose uptake
L Bouraoui, E Capilla, J Gutiérrez… - American Journal of …, 2010 - journals.physiology.org
Primary cultures of rainbow trout (Oncorhynchus mykiss) adipocytes were used to examine
the main signaling pathways of insulin and insulin-like growth factor I (IGF-I) during …
the main signaling pathways of insulin and insulin-like growth factor I (IGF-I) during …
IMP1 mediates tumor size and dissemination into the blood in colorectal cancer cell xenografts.
KE Hamilton, PS Katti, CM Hahn, SR Davey… - Cancer Research, 2013 - AACR
Introduction Colorectal cancer (CRC) remains amongst the top causes of cancer-related
deaths in the United Sates, with nearly 60,000 deaths per year. Despite significant emphasis …
deaths in the United Sates, with nearly 60,000 deaths per year. Despite significant emphasis …