Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies

L Lu, G Chen, Y Qiu, M Li, D Liu, D Hu, X Gu, Z Xiao - Science Bulletin, 2016 - Elsevier
Colon-targeted oral delivery is crucial for the treatment of colon-related diseases, as this
delivery strategy enables precise drug administration to the diseased site, enhances drug …

Oral nano-delivery systems for colon targeting therapy

T Zhang, G Zhu, B Lu, Q Peng - Pharmaceutical …, 2017 - ingentaconnect.com
Background: Targeting drug delivery is an attractive research area, as it enables localized
treatment, improves the efficacy of therapeutics and reduces systemic toxicity. Colon …

Advances in colon-targeted nano-drug delivery systems: challenges and solutions

M Naeem, UA Awan, F Subhan, J Cao… - Archives of pharmacal …, 2020 - Springer
Nano-drug delivery systems (NDDS) for colon-targeted drug delivery are an active area of
research on local diseases affecting the colon, such as ulcerative colitis, Crohn's disease …

[HTML][HTML] Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: selective targeting to diseased versus healthy tissue

S Hua, E Marks, JJ Schneider, S Keely - … : nanotechnology, biology and …, 2015 - Elsevier
Colon targeted drug delivery is an active area of research for local diseases affecting the
colon, as it improves the efficacy of therapeutics and enables localized treatment, which …

Nanoparticle-based oral drug delivery systems targeting the colon for treatment of ulcerative colitis

M Zhang, D Merlin - Inflammatory bowel diseases, 2018 - academic.oup.com
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), is characterized by chronic relapsing inflammation of the gastrointestinal tract. Delivery …

Strategies and opportunities of micro/nano delivery systems for targeted therapy of ulcerative colitis: Focus on underlying mechanisms and future perspectives

Z Liu, H Liu, J Cheng, H Wang, Y Yang, J Ye… - Chinese Chemical …, 2023 - Elsevier
Ulcerative colitis (UC) is a common progressive inflammatory disease whose incidence has
increased rapidly in recent years, and can develop into colorectal cancer in severe cases …

Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease

B Xiao, D Merlin - Expert opinion on drug delivery, 2012 - Taylor & Francis
Introduction: Inflammatory bowel disease (IBD) is a chronic relapsing idiopathic disease. In
clinical terms, most patients require lifelong medication associated with possible unpleasant …

Role of nanoparticle size, shape and surface chemistry in oral drug delivery

A Banerjee, J Qi, R Gogoi, J Wong… - Journal of Controlled …, 2016 - Elsevier
Nanoparticles find intriguing applications in oral drug delivery since they present a large
surface area for interactions with the gastrointestinal tract and can be modified in various …

Current Advances of Nanomaterial-Based Oral Drug Delivery for Colorectal Cancer Treatment

N Wang, L Chen, W Huang, Z Gao, M Jin - Nanomaterials, 2024 - mdpi.com
Colorectal cancer (CRC) is a common malignant tumor, and traditional treatments include
surgical resection and radiotherapy. However, local recurrence, distal metastasis, and …

Nanoparticles for oral delivery: Design, evaluation and state-of-the-art

AA Date, J Hanes, LM Ensign - Journal of Controlled Release, 2016 - Elsevier
The oral route is a preferred method of drug administration, though achieving effective drug
delivery and minimizing off-target side effects is often challenging. Formulation into …