• Wise-Faberowski et al: Volatile versus narcotic anesthetic for surgical repair of congenital
heart disease: the effect on postoperative EEG--Infants undergoing surgical repair for CHD …

There is an increasing concern regarding the risk of anaesthetic neurotoxicity in children.
Numerous animal and in vitro studies have demonstrated that general anaesthetics cause a …

Relatively enriched pre‐clinical data suggest that commonly used general anesthetics can
cause widespread neuronal apoptosis with potentially long‐term neurocognitive deficits in …

Approximately 1.5 million neonates receive general anaesthesia each year for surgical
procedures. Providing anaesthesia to neonates is not easy. Surgical procedures are often …

The data on whether neuronal toxicity arises from the use of certain anesthetics in the brains
of laboratory animals raise the question whether standard clinical anesthesia practice could …

Laboratory work has confirmed that general anesthetics cause increased neuronal
apoptosis and changes to the morphology of dendritic spines in the developing brains of …

Over the past few years, a great amount of attention has been focused on the possibility that
anesthetics may be toxic to neurons in the fetal and newborn brain. In rodents, clinically …

Pre-clinical studies have consistently found that most general anaesthetics produce
accelerated apoptosis in the developing brain. The effect has been seen in species ranging …

The fetal and neonatal periods are critical and sensitive periods for neurodevelopment, and
involve rapid brain growth in addition to natural programmed cell death (ie, apoptosis) and …