摘要背景肝X 受体(liver X receptors, LXRs) 包括LXRα 和LXRβ 属于核激素受体超家族成员,
是配体依赖的转录调节因子, 目前已知LXR 在体内作为脂质感受器, 参与了一系列胆固醇和 …

Liver X receptors (LXRs) regulate lipogenesis and inflammation, but their contribution to the
metabolic syndrome is unclear. We show that LXRs modulate key aspects of the metabolic …

Regulation of nutrient balance by the liver is important to ensure whole body metabolic
control. Hepatic expression of genes involved in lipid and glucose metabolism is tightly …

Aims/hypothesis Liver X receptors (LXR) are important transcriptional regulators of lipid and
glucose metabolism. Our previous report demonstrated that LXR activation inhibited …

Aim: Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent causes of liver
dysfunction and its incidence has increased markedly. However, the mechanisms involved …

The liver X receptors, LXRα (NR1H3) and LXRβ (NR1H2), are ligand-activated transcription
factors that belong to the nuclear hormone receptor superfamily. LXRs play a critical role in …

Liver X receptors (LXRα and LXRβ) regulate glucose and lipid metabolism. Pancreatic β-
cells and INS-1E insulinoma cells express only the LXRβ isoform. Activation of LXRβ with …

The functions of the liver X receptors (LXRs) are not well documented in adipose tissue. We
demonstrate here that expression of the LXRα gene is highly induced in vivo and in vitro in …

Liver X receptor (LXR) α and LXRβ are nuclear oxysterol receptors whose biological
function has so far been elucidated only with respect to cholesterol and lipid metabolism. To …

Liver X receptor (LXR) α and LXRβ play key roles in hepatic de novo lipogenesis through
their regulation of lipogenic genes, including sterol regulatory element-binding protein …